Original Article: PDF OnlyPulmonary Adenofibromas A Clinicopathologic Correlation of 13 CasesLindholm, Kaleigh E. MD*; Sansano-Valero, Irene MD†; Rodriguez, Jorge L. MD†; Ramon y Cajal, Santiago MD†; Moran, Cesar A. MD‡Author Information *Department of Pathology, University of Colorado, Denver, CO †Department of Pathology, Vall D’Hebron Hospital, Barcelona, Spain ‡Department of Pathology, MD Anderson Cancer Center, University of Texas, Houston, TX Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Correspondence: Cesar A. Moran, MD, Department of Pathology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 (e-mail: email@example.com). The American Journal of Surgical Pathology: February 19, 2020 - Volume Publish Ahead of Print - Issue - doi: 10.1097/PAS.0000000000001456 Buy PAP Metrics Abstract Thirteen cases of primary pulmonary adenofibromas are presented. The patients are 8 women and 5 men between the ages of 41 and 73 years (average: 57 y). The patients presented with nonspecific symptomatology or their tumor was identified during routine chest films. A wedge resection was performed in all cases with lymph node sampling. Grossly, the tumors varied in size from 1 to 2.5 cm in greatest dimension. The entire tumor was histologically evaluated in all cases. All the tumors shared similar histologic features namely leaf-like/phyllodes-like growth patterns with varying areas of sclerosis, focal inflammation, and entrapped epithelium. A wide panel of immunohistochemical studies was performed including epithelial, neural, muscle, and vascular markers, all of which showed negative staining. The tumors were positive only for vimentin in the stroma and keratin in the entrapped epithelium. Further evaluation in 6 cases using in situ hybridization for the solitary fibrous tumor was performed and was negative. Clinical follow-up in all the patients showed no evidence of recurrence or metastatic disease, during a period of 12 to 36 months. The current cases highlight the unusual occurrence of pulmonary adenofibromas and the importance of separating these tumors from other tumors that may have the potential to recur or metastasize. The use of proper immunohistochemical stains/molecular analysis aids in the proper classification of these tumors. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.