Original Article: PDF OnlyA Modified Histopathologic Staging in Penile Squamous Cell Carcinoma Predicts Nodal Metastasis and Outcome Better Than the Current AJCC StagingSali, Akash P. MD*,†; Menon, Santosh MD*; Murthy, Vedang MD‡; Prakash, Gagan DNB§; Bakshi, Ganesh MCh§; Joshi, Amit DM∥; Desai, Sangeeta B. MD*Author Information Departments of *Pathology ‡Radiation Oncology §Surgical Oncology ∥Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra †Department of Pathology, Homi Bhabha Cancer Hospital, Sangrur, Punjab, India Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Correspondence: Santosh Menon, MD, Department of Pathology, Tata Memorial Hospital, Tata Memorial Centre, 8th Floor, Annex Building, Dr E. Borges Road, Parel, Mumbai 400012, Maharashtra, India (e-mail: email@example.com). The American Journal of Surgical Pathology: April 14, 2020 - Volume Publish Ahead of Print - Issue - doi: 10.1097/PAS.0000000000001490 Buy PAP Metrics Abstract Recently, the American Joint Committee on Cancer (AJCC) updated the staging system for penile squamous cell carcinoma. According to it, unlike its previous version, the involvement of urethra does not upstage the tumor; however, the involvement of corpora cavernosa (CC) does. The tumors involving CC are now staged pT3, whereas those involving corpora spongiosa (CS) are staged pT2, irrespective of the involvement of the urethra. In the current study, we sought to validate these recent modifications and in-process also attempted to improvise upon it. The histopathology slides were reviewed in 142 cases of penile squamous cell carcinoma. The histopathologic variables noted were tumor grade, anatomic level of invasion (CC/CS), lymphovascular invasion (LVI), and perineural invasion (PNI). Metastases to the lymph nodes were confirmed. Tumors were staged pT2/pT3 according to AJCC 8th edition and this staging system was further improvised by incorporating histopathologic variables similar to pT1 tumors in AJCC 8th edition. Accordingly, pT2 tumors invaded CS/CC without LVI or PNI and were not grade 3, whereas pT3 tumors invaded CS/CC, showed LVI and/or PNI, or were grade 3. Both the staging models were then correlated with nodal metastasis and disease-free survival. The new staging model (P=0.001) and not the AJCC pT2/pT3 stages (P=0.2) showed a statistically significant correlation with nodal metastasis. Similarly, only the proposed model significantly impacted disease-free survival (P=0.011). To conclude, we were unable to validate the prognostic difference between the pT2/pT3 stages according to AJCC 8th edition. The staging system can be improvised by incorporating histopathologic variables similar to pT1 tumors. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.