Original ArticlesAdenovirus Hepatitis Clinicopathologic Analysis of 12 Consecutive Cases From a Single InstitutionSchaberg, Kurt B. MD; Kambham, Neeraja MD; Sibley, Richard K. MD; Higgins, John P.T. MDAuthor Information Department of Pathology, Stanford University School of Medicine, Stanford, CA The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Correspondence: Kurt B. Schaberg, MD, Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324 (e-mail: email@example.com). The American Journal of Surgical Pathology: June 2017 - Volume 41 - Issue 6 - p 810-819 doi: 10.1097/PAS.0000000000000834 Buy Metrics Abstract Adenoviruses are common pathogens that usually cause self-limited infections. However, in the immunocompromised host they can cause severe infections involving multiple organs including the liver. A search of the pathology database at Stanford University Medical Center (1995 to 2016) identified 12 cases of adenovirus hepatitis including biopsy and autopsy specimens. There were 8 pediatric patients, 7 of which had received orthotropic liver transplants and 1 of which was receiving chemotherapy for lymphoblastic leukemia. There were 4 adult patients, of which 1 was actively receiving chemotherapy for chronic lymphocytic leukemia and 2 had undergone hematopoietic stem cell transplantation for hematologic malignancies. One patient had lymphoplasmacytic lymphoma and had received chemotherapy over a year prior but was not receiving therapy at the time he contracted adenovirus hepatitis. In all cases, histologic sections showed nonzonal coagulative hepatocyte necrosis and characteristic intranuclear inclusions. Hepatocyte necrosis ranged from spotty to massive. The majority of cases (7/12; 58%) had no associated inflammation. If present, inflammation was focal and lymphohistiocytic. In 1 case, findings were focal within the liver, requiring an image-guided biopsy. This patient underwent a simultaneous nontargeted liver biopsy that lacked histologic evidence of adenovirus. Among the pediatric patients, 63% (5/8) died secondary to organ failure, while there was 100% (4/4) mortality in the adult population. Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.