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NF1 Mutations Are Common in Desmoplastic Melanoma

Wiesner, Thomas MD*,†; Kiuru, Maija MD, PhD*; Scott, Sasinya N. BS*,†; Arcila, Maria MD*; Halpern, Allan C. MD; Hollmann, Travis MD, PhD*; Berger, Michael F. PhD*,†; Busam, Klaus J. MD*

The American Journal of Surgical Pathology: October 2015 - Volume 39 - Issue 10 - p 1357–1362
doi: 10.1097/PAS.0000000000000451
Original Articles
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Desmoplastic melanoma (DM) is a rare variant of melanoma with distinct clinical, histopathologic, and immunohistochemical features. Clinically, DM differs from conventional melanoma by a higher propensity for local recurrence and less frequent metastatic spread to regional lymph nodes. In its pure form, DM has a distinct appearance displaying a low density of fusiform melanocytes in a collagen-rich matrix. Whereas a number of mutations have been identified in primary melanoma, including BRAF, NRAS, GNAQ, GNA11, and KIT, and the occurrence of these mutations has been found to correlate to some extent with the histopathologic features, anatomic site, and/or mode of sun exposure, no distinct set of mutations has so far been reported for DM. To study the potential association of neurofibromin (NF1) mutations with DM, we examined 15 desmoplastic and 20 non-DMs by next-generation sequencing. Mutations of the NF1 gene were found in 14 of 15 (93%) DMs and 4 of 20 (20%) non-DMs. The high frequency of NF1 mutations in DMs suggests an important role for NF1 in the biology of this type of melanoma.

*Department of Pathology

Human Oncology and Pathogenesis Program

Department of Medicine, Dermatology Service, Memorial Sloan-Kettering Cancer Center, New York, NY

T.W. and M.K. made comparable contributions to the study and should be considered as co-first authors.

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conflicts of Interest and Source of Funding: Supported by grants from the Harry J. Lloyd Trust - Translational Research Grant to K.J.B. and T.W. and the Charles H. Revson Senior Fellowship to T.W. Research reported in this publication was supported in part by the Cancer Center Support Grant of the National Institutes of Health/National Cancer Institute under award number P30CA008748. The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Correspondence: Klaus J. Busam, MD, Department of Pathology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (e-mail: busamk@mskcc.org).

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