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Well-differentiated Osteosarcoma of the Jaw Bones: A Clinicopathologic Study of 15 Cases

Demicco, Elizabeth G. MD, PhD*; Deshpande, Vikram MD*; Nielsen, G. Petur MD*; Kattapuram, Susan V. MD; Rosenberg, Andrew E. MD*

The American Journal of Surgical Pathology: November 2010 - Volume 34 - Issue 11 - p 1647-1655
doi: 10.1097/PAS.0b013e3181f7dac6
Original Articles

Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66 y; mean 42.8 y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.

Departments of *Pathology

Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA

Correspondence: Andrew E. Rosenberg, MD, Department of Pathology (WRN 2), Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114 (e-mail:

© 2010 Lippincott Williams & Wilkins, Inc.