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Hybrid Myxoinflammatory Fibroblastic Sarcoma/Hemosiderotic Fibrolipomatous Tumor: Report of a Case Providing Further Evidence for a Pathogenetic Link

Elco, Christopher P. MD, PhD*; Mariño-Enríquez, Adrián MD* †; Abraham, John A. MD; Cin, Paola Dal PhD*; Hornick, Jason L. MD, PhD*

The American Journal of Surgical Pathology: November 2010 - Volume 34 - Issue 11 - p 1723-1727
doi: 10.1097/PAS.0b013e3181f17d51
Case Reports

Myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor are rare, slow-growing soft tissue tumors of the distal extremities with recurrent potential. Recent cytogenetic studies have shown a t(1;10)(p22;q24) or der(10)t(1;10) in combination with aberrations of chromosome 3 in a limited number of cases of both entities. Here we report a case of a 42-year-old female with a soft tissue tumor of the ankle showing hybrid morphologic features of myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor, a der(10)t(1;10), and abnormalities of chromosome 3. This hybrid lesion provides further evidence for a close relationship between these 2 tumor types.

*Department of Pathology, Brigham and Women's Hospital

Center for Bone and Sarcoma Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Departamento de Anatomía Patológica, Hospital Universitario La Paz, Universidad Autónoma, Madrid, Spain

Adrián Mariño-Enríquez is supported by a research grant from Fundación Alfonso Martín Escudero, Madrid, Spain.

Correspondence: Jason L. Hornick, MD, PhD, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115 (e-mail:

Christopher P. Elco and Adrián Mariño-Enríquez have contributed equally to this work.

© 2010 Lippincott Williams & Wilkins, Inc.