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Lymphohistiocytoid Variant of Malignant Mesothelioma of the Pleura: A Series of 22 Cases

Galateau-Sallé, Francoise MD* † ‡; Attanoos, Richard MD§; Gibbs, Allen R. MD§; Burke, Louise MD, FRCPath* ∥; Astoul, Philippe MD; Rolland, Patrick; Ilg, Anabelle Gilg soit; Pairon, Jean Claude MD; Brochard, Patrick MD; Begueret, Hugues MD*; Vignaud, Jean Michel MD*; Kerr, Keith MD, FRCPath; Launoy, Guy MD, PhD; Imbernon, Ellen MD; Goldberg, Marcel MD

The American Journal of Surgical Pathology: May 2007 - Volume 31 - Issue 5 - p 711-716
doi: 10.1097/PAS.0b013e31802baad7
Original Articles

The lymphohistiocytoid variant of diffuse malignant mesothelioma is rare with very few cases described in the literature. It is characterized by mesothelial cells with a histiocytelike appearance and an associated dense lymphoid infiltrate. We studied clinicopathologic features and immunohistochemical patterns of a series of 22 cases. The histiocytelike cells had a mesothelial immunophenotype: AE1/AE3 (100%), calretinin (100%), CK5/6 (46%), and EMA (52%). The prominent lymphoid component showed a cytotoxic T-cell immunophenotype. Prognosis was similar to that of a large series of epithelioid diffuse malignant mesotheliomas. Formely, it was classified within the sarcomatoid type. We suggest that it should be reclassified as an epithelioid variant because of its similar behavioural characteristics. There was no evidence of Epstein-Barr virus-related infection.

*Mesopath Group, ERI 3 Inserm, CHU Caen

InVs, Hopital Saint Maurice, Vincennes

ERI 3 Inserm, CHU Caen, France

§Department of Histopathology, Llandough Hospital, Cardiff

Department of Pathology, University of Aberdeen, UK

Histopathology Department, Cork University Hospital, Wilton Cork, Ireland

Supported by the “Institut de Veille Sanitaire” Hopital Saint Maurice, Vincennes, and by grants from the Conseil Régional de Basse Normandie, France.

On the Behalf of the Mesopath Group: A. deQuillacq, I. Abdalsamad, E. Brambilla, F. Capron, MC. Copin, AY. deLajartre, A. Foulet-Rogé, L. Garbe, O. Groussard, L. Guillou, JM. Piquenot, F. Thivolet.

Reprints: Prof Francoise Galateau-Sallé, MD, CHU Caen Cote de Nacre, Avenue Cote de Nacre, Caen, Calvados, France, 14033 Caen Cedex (e-mail:

© 2007 Lippincott Williams & Wilkins, Inc.