Original ArticlesRenal Cell Carcinoma Associated With Prominent Angioleiomyoma-like Proliferation Report of 5 Cases and Review of the LiteratureKuhn, Elisabetta MD*; De Anda, Jazmìn MD†; Manoni, Samanta MD‡; Netto, George MD§; Rosai, Juan MD* ∥ Author Information *Centro Consulenze Anatomia Patologica Oncologica, Centro Diagnostico Italiano, Milan, Italy †Department of Pathology, Institute National of Pediatrics, Mexico City, Mexico ‡Department of Pathology, University of Bologna, Bologna, Italy §Department of Pathology, Johns Hopkins Medical Institutions, Baltimore ∥Genzyme Genetics, Inc, New York, NY The American Journal of Surgical Pathology: November 2006 - Volume 30 - Issue 11 - p 1372-1381 doi: 10.1097/01.pas.0000213277.45715.82 Buy Metrics Abstract Five cases of renal cell carcinoma of clear cell type are presented, Fuhrmann's grade 2, associated with a peculiar stromal proliferation having angioleiomyoma-like features. This proliferation was particularly prominent at the interphase between the tumor edge and the surrounding normal tissues, in which it acquired the configuration of a tumor capsule. Four similar cases were taken from the literature. We postulate that this angioleiomyoma-like change is a tumor epiphenomenon and that it represents yet another manifestation of the well-documented capacity of renal cell carcinoma to induce vascular proliferation, probably through the secretion of angiogenic and other growth factors by the tumor cells. © 2006 Lippincott Williams & Wilkins, Inc.