Original ArticleCylindroma of the Breast of Skin Adnexal Type A Study of 4 CasesNonaka, Daisuke MD*; Rosai, Juan MD*; Spagnolo, Dominic MBBS, FRCPA†; Fiaccavento, Sergio MD‡; Bisceglia, Michele MD§Author Information From the *Department of Pathology, National Cancer Institute, Milan, Italy; †Western Australian Centre for Pathology and Medical Research, Nedlands, Australia; ‡Anatomic Pathology Service, Casa di Cura Poliambulanza, Brescia, Italy; and the §Department of Pathology, IRCCS-Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo (FG), Italy. Reprints: Daisuke Nonaka, MD, Department of Pathology, Istituto Nazionale Tumori, Via G. Venezian 1, 20133 Milan, Italy (e-mail: [email protected]). The American Journal of Surgical Pathology: August 2004 - Volume 28 - Issue 8 - p 1070-1075 doi: 10.1097/01.pas.0000126774.27698.27 Buy Metrics Abstract Four cases of solitary cylindroma of the breast of skin adnexal type are described. The tumors were morphologically and immunophenotypically identical to their dermal counterparts. They arose in close proximity to the nipple, such as the retroareolar area of the breast and in intimate association with the lactiferous ducts, suggesting an origin from the latter structures. One case occurred in a woman with hereditary multiple cylindromatosis (Brooke-Spiegler syndrome). This is the second reported case of this hereditary syndrome with extracutaneous manifestations and the first case in which the breast is involved. © 2004 Lippincott Williams & Wilkins, Inc.