Case ReportSolitary Fibrous Tumor of the Cerebellopontine Angle With Salivary Gland Heterotopia: A Unique PresentationRodriguez, Fausto MD*; Scheithauer, Bernd W. MD*; Ockner, Daniel M. MD†; Giannini, Caterina MD, PhD*Author Information From the *Department of Pathology, Mayo Foundation, Rochester, Minnesota; and †Christiana Care Health Services, Wilmington, Delaware. Reprints: Caterina Giannini, MD, Department of Pathology, Mayo Clinic, Rochester, MN 55902 (e-mail: Giannini.Caterina@Mayo.edu). The American Journal of Surgical Pathology: January 2004 - Volume 28 - Issue 1 - p 139-142 Buy SDC Abstract We report the unique association of a solitary fibrous tumor of the cerebellopontine angle with ectopic salivary gland tissue in a 53-year-old woman. The patient, diagnosed 21 years earlier with a right cerebellopontine angle fibrous meningioma, presented with a recurrent mass, which, upon surgical removal, showed features of a solitary fibrous tumor. Strong and diffuse immunoreactivity to CD34 and BCL-2 and a negative epithelial membrane antigen immunostain confirmed the diagnosis. Admixed with the spindle cell neoplasm, a bland glandular element composed of small glands and variably dilated tubules was noted. The vague tubuloacinar arrangement of the glands and the presence of acinar cells with a granular, periodic acid-Schiff-positive, basophilic cytoplasm, resembling serous type acini, were features of benign, although ectopic, salivary gland tissue. The presence of a myoepithelial cell layer, surrounding some of the acini and highlighted by the smooth muscle actin immunostain, strengthened this interpretation. © 2004 Lippincott Williams & Wilkins, Inc.