ORIGINAL ARTICLESMetastatic Tumors of the Vulva A Clinicopathologic Study of 66 CasesNeto, Antonio G. M.D.; Deavers, Michael T. M.D.; Silva, Elvio G. M.D.; Malpica, Anais M.D.Author Information From the Department of Pathology (A.G.N.), University of Texas Medical School, and the Department of Pathology (M.T.D., E.G.S., A.M.), University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A. Presented in part at the 91st U.S. and Canadian Academy of Pathology Meeting, Chicago, Illinois, 2002. Address correspondence and reprint requests to Anais Malpica, MD, Department of Pathology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, U.S.A.; e-mail: [email protected] The American Journal of Surgical Pathology: June 2003 - Volume 27 - Issue 6 - p 799-804 Buy Abstract Metastatic tumors involving the vulva are rare, with only a few series and case reports published in the English literature to date. In this study, we present the clinicopathologic features of 66 cases of metastatic tumors of the vulva seen at the University of Texas M. D. Anderson Cancer Center from 1944 to 2001. The patients' age ranged from 18 to 84 years (mean 54.8 years). The most common presentations were vulvar nodules or a mass (39 cases), pain (7 cases), and ulceration (5 cases). In 46.9% of cases, the primary tumor was of gynecologic origin, whereas in 43.9% of cases the primary tumor was of nongynecologic origin. The remainder had unknown primaries. The site most frequently involved by metastasis was the labium majus (44 cases: 18 on the right, 13 on the left, 6 bilateral, and 7 unspecified side). Thirty percent of the patients received chemotherapy as treatment for the metastasis, 27% received radiotherapy, and the rest received some combination of chemotherapy, radiotherapy, and surgery. Of the 60 patients with available follow-up, 52 died of disease within 1–81 months (median 7.5 months) from diagnosis of the metastasis. Metastatic tumors of the vulva are rare; however, the diagnosis of these tumors is facilitated by the knowledge of a preexistent malignancy and the lack of a mucocutaneous intraepithelial lesion. © 2003 Lippincott Williams & Wilkins, Inc.