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Mesonephric Adenocarcinoma of the Uterine Corpus: CD10 Expression as Evidence of Mesonephric Differentiation

Ordi, Jaume M.D.; Nogales, Francisco F. M.D.; Palacin, Antonio M.D.; Márquez, Manuel M.D.; Pahisa, Jaume M.D.; Vanrell, Juan A. M.D.; Cardesa, Antonio M.D.

The American Journal of Surgical Pathology: December 2001 - Volume 25 - Issue 12 - p 1540-1545
Case Reports

Mesonephric (wolffian) neoplasms of the female genital tract are infrequent and found in sites where embryonic remnants of wolffian origin are usually detected, such as the uterine cervix, broad ligament, mesosalpinx, and ovary. Their diagnosis is difficult because of the absence of specific immunohistochemical markers for mesonephric derivatives. We present the first report of adenocarcinoma of mesonephric type arising as a purely myometrial mass without endometrial or cervical involvement in the uterine corpus of a 33-year-old woman. The tumor showed a combination of patterns, with retiform areas, ductal foci, and small tubules with eosinophilic secretion, which merged with solid sheets of cells with a sarcomatoid appearance. Immunohistochemically, neoplastic cells were diffusely positive for cytokeratin 7, epithelial membrane antigen, and CD15 and focally positive for BerEP4 and vimentin. A hitherto unreported feature was the positivity for CD10 in neoplastic cells, which was also present in a large number of control tissues obtained from male mesonephric derivatives and female mesonephric remnants and tumors. Furthermore, CD10 was negative in controls from müllerian epithelia of the female genital tract and in their corresponding tumors. Therefore, the expression of CD10 by mesonephric remnants may be useful in establishing the diagnosis of tumors with mesonephric differentiation.

From the Department of Pathology (J.O., A.P., M.M., A.C.) and Institut Clínic de Ginecologia, Obstetrícia i Neonatologia (J.P., J.A.V.), Hospital Clínic-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, School of Medicine, Barcelona, and University Hospital (F.F.N.), Granada, Spain.

Address correspondence and reprint requests to Jaume Ordi, MD, Department of Pathology, Hospital Clínic, C/Casanova 143, 08036-Barcelona, Spain; e-mail:

© 2001 Lippincott Williams & Wilkins, Inc.