CASE REPORTSAcute Measles Gastric InfectionVieth, M.; Dirschmid, K.; Oehler, U.; Helpap, B.; von Luckner, A. Graf; Stolte, M.Author Information From the Institut für Pathologie (M.V., K.D., M.S.), Klinikum Bayreuth, Bayreuth; the Institut für Pathologie (U.O., B.H.), Hegau-Klinikum, Singen; and the Universität Freiburg Lehrbereich Allgemeinmedizin (A.G.V.L.), Freiburg, Germany. A monoclonal antibody and the control slide kit were provided by Argene Biosoft, France. Address correspondence and reprint requests to Professor Dr. med. M. Stolte, Institut für Pathologie, Klinikum Bayreuth, 95445 Bayreuth, Germany. E-mail: [email protected] The American Journal of Surgical Pathology: February 2001 - Volume 25 - Issue 2 - p 259-262 Buy Abstract We describe the case of a 44-year-old man who was referred for gastroscopy because of abdominal pain. During endoscopy, inflammatory changes of the antrum and corpus mucosa were clearly visible, and biopsy samples from the antrum and corpus mucosa were taken. At histology, routine hematoxylin and eosin staining showed characteristics indicative of so-called ex-Helicobacter pylori-gastritis that had developed after antibiotic treatment 2 years ago. Additional large, bizarre inclusion bodies and clusters of multinucleated giant cells were located in the surface epithelium and within the lamina propria. These giant cells had an appearance similar to that of Warthin-Finkeldey cells, which can be found during the prodromal phase of measles infection. Anti-measles virus immunochemistry showed a strong positivity for measles virus antigen within the giant cells. Based on these results, the final diagnosis of morbilliform gastritis was made. To our knowledge, no case of measles gastritis has been described in the literature. Our case report confirms the systemic character of measles virus infection and confirms that measles viral replication can involve the gastric mucosa in addition to the conjunctiva, lung, and intestina. © 2001 Lippincott Williams & Wilkins, Inc.