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Endocrine Mucin-Producing Sweat Gland Carcinoma: A Cutaneous Neoplasm Analogous to Solid Papillary Carcinoma of Breast

Flieder, Andrea M.D.; Koerner, Frederick C. M.D.; Pilch, Ben Z. M.D.; Maluf, Horacio M. M.D.

The American Journal of Surgical Pathology: December 1997 - Volume 21 - Issue 12 - p 1501-1506
Original Articles

We describe two cases of a distinctive in situ and invasive cutaneous adnexal neoplasm occurring in the eyelid. Mucinous carcinoma represented the invasive portion of the tumor in one case, whereas the other infiltrated in small solid nests. The in situ component is identical to the recently described solid papillary carcinoma of the breast (endocrine ductal carcinoma in situ). Both tumors produced intra- and extracellular mucin, exhibited endocrine differentiation by immunohistochemistry and ultrastructural analysis, and were positive for estrogen and progesterone receptors.

From the Departments of Pathology of the Massachusetts General Hospital, Boston, Massachusetts (A.F., F.K., B.P.), and the Veterans Affairs Medical Center, Memphis, Tennessee (H.M.), USA.

Address correspondence and reprint requests to Dr. Horacio M. Maluf, Pathology and Laboratory Medicine Service (113), Veterans Affairs Medical Center, 1030 Jefferson Ave., Memphis, TN 38104-2193, USA.

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