ORIGINAL ARTICLES: PDF OnlySpindle Cell Epithelioma, the So-called Mixed Tumor of the Vagina A Clincopathologic, Immunohistochemical, and Ultrastructural Analysis of 28 CasesBranton, Philip A. CPT, MC; Tavassoli, Fattaneh A. M.D.Author Information Department of Pathology and Area Laboratory Services (P.A.B.) Walter Reed Army Medical Center; and the Department of Gynecologic and Breast Pathology (F.A.T.), Armed Forces Institute of Pathology, Washington, DC 20307, U.S.A. The American Journal of Surgical Pathology: May 1993 - Volume 17 - Issue 5 - p 509-515 Buy Abstract A total of 28 examples of vaginal mixed tumors, a circumscribed tumor composed predominantly of spindle cells, but often admixed with minor glandular, and focal areas of squamous differentiation along with localized hyaline globules, were evaluated. In addition to the clinicopathologic correlation with light microscopy, 10 cases were analyzed immunohistochemically by a panel of antibodies for keratin, smooth muscle actin, S-100 protein, and glial fibrilary acidic protein; five cases were also evaluated for estrogen and progesterone receptors. Ultrastructural analysis was performed on two tumors. The results indicate an epithelial differentation in the predominating spindle cells based upon an intense immunoreaction with cytokeratin in nine of 10 cases and the presence of tonofilaments and desmosomes at the ultrastructural level. Contrary to mixed tumors of salivary gland and breast oring, no evidence of a myoepithelial differentiation was identified in these tumors. The name vaginal spindle cell epithelioma is proposed for these neoplasms as being more descriptive of the true nature of these tumors. © Lippincott-Raven Publishers.