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Lymphoepithelioma-like Carcinoma of the Lung

Butler Alexandra E. M.B.B.S.; Colby, Thomas V. M.D.; Weiss, Laurence M.D.; Lombard, Charles M.D.
The American Journal of Surgical Pathology: August 1989
Original Article: PDF Only

Originally described in the nasopharynx, lymphoepitheliomas are undifferentiated carcinomas with prominent lymphoid infiltration. Recently this tumor has been described in a number of other sites. An association with prior infection by the Epstein-Barr virus has been recognized in cases from the nasopharynx. We report four cases of lymphoepithelioma-like carcinoma arising in the lung. Epstein-Barr virus serology indicated prior infection in two cases, one of which was also found by in situ hybridization to have the virus genome. Lymphoepithelioma-like carcinoma must be considered in the differential diagnosis of primary lung tumors, particularly when an extensive infiltrate by lymphoid tissue is present and may even suggest lymphoma.

© Lippincott-Raven Publishers.