Original Article: PDF OnlyExpression of Glial Fibrillary Acidic Protein (GFAP) in Peripheral Nerve Sheath Tumors A Comparative Study of Immunoreactivity of GFAP, Vimentin, S-100 Protein, and Neurofilament in 38 Schwannomas and 18 NeurofibromasKawahara, Ei M.D.; Oda, Yoshio M.D.; Ooi, Akishi M.D.; Katsuda, Shogo M.D.; Nakanishi, Isao M.D.; Umeda, Shinichiro M.D.Author Information From the Departments of Pathology (E.K., Y.O., A.O., S.K., I.N.) and Orthopedic Surgery (S.U.), School of Medicine, Kanazawa University, Kanazawa, Japan. The American Journal of Surgical Pathology: February 1988 - Volume 12 - Issue 2 - p 115-120 Buy Abstract Immunoreactivity of glial fibrillary acidic protein (GFAP) in 38 schwannomas and 18 neurofibromas was evaluated and compared with the reactivity of vimentin, S-100 protein, and neurofilament protein. All cases were positive for vimentin and S-100 protein. GFAP was positively stained in the neoplastic cells of 15 of 38 schwannomas (38%) and in two of 18 neurofibromas (11%). The extensively stained GFAP-positive tumors tended to be deeply situated in the body. The GFAP-positive cells were usually spindle-shaped and appeared preferentially in the perivascular region of hyalinized, thick blood vessels. © Lippincott-Raven Publishers.