Secondary Logo

Journal Logo


Physical Medicine and Rehabilitation and Pulmonary Rehabilitation for COVID-19

Wang, Tina J. MD; Chau, Brian MD; Lui, Mickey DO; Lam, Giang-Tuyet MD; Lin, Nancy MD; Humbert, Sarah MD

Author Information
American Journal of Physical Medicine & Rehabilitation: September 2020 - Volume 99 - Issue 9 - p 769-774
doi: 10.1097/PHM.0000000000001505
  • Free


This review is written to empower physical medicine and rehabilitation (PM&R) physicians as many of us are called to assist our colleagues in the fight against COVID-19. The PM&R perspective and pulmonary rehabilitation lend unique tools to our medical teams as we work to combat a disease currently without definitive treatment other than supportive care.

These recommendations are extrapolated from studies and experience in patients with COVID-19, pulmonary rehabilitation patients without COVID-19, and from previous severe acute respiratory syndrome (SARS)/Middle East respiratory syndrome epidemic.1,2 Flexibility and synthesis of heterogeneous and multidisciplinary data and experience across specialties are necessary to address the new and unique rehabilitation challenges that arise from this pandemic. This review serves as a guide and launching point for the ongoing management of functional and comorbid rehabilitative issues related to COVID-19.

Pulmonary rehabilitation’s definition, as adapted from the American Thoracic Society/European Respiratory Society,3 is comprehensive intervention based on a thorough patient assessment, followed by patient-tailored therapies that include, but are not limited to, exercise training, education, and behavior change, designed to improve the physical condition of people with respiratory disease.

The purpose of pulmonary rehabilitation in COVID-19 patients is to improve symptoms of dyspnea, relieve anxiety, reduce complications, minimize disability, preserve function, and improve quality of life.4 Pulmonary rehabilitation should be tailored to each individual patient. In the event that a PM&R physician or a rehabilitation expert is not available, proposed interventions have been listed.

A PubMed search was conducted using a systematic review filter to identify articles that were published since January 2003 to include the SARS outbreak. Reviews were selected from a systematic search for literature containing information related to COVID-19, Middle East respiratory syndrome, and SARS. Five board-certified PM&R physicians scoured additional sources including professional blogs and membership forums.


Given the shortage of personal protective equipment and high risk of nosocomial spread, rehabilitation should occur through telemedicine with minimal contact. Self-supervised rehabilitation should be initiated using telemedicine.2,5 Previous studies on the use telehealth and home pulmonary rehabilitation programs showed equal outcomes compared with center based programs.6 If direct supervision is needed, full personal protective equipment including gloves, mask, and isolation gown should be used in all person-to person interaction. Furthermore, a face shield and/or goggles are also recommended if there is risk of infected aerosolized droplets. Current noninvasive ventilatory techniques have a high risk of aerosolization of the SARS-CoV-2 virus.7,8 Nosocomial spread among healthcare workers is extremely high (approximately 35% of exposed healthcare workers develop disease),9 and the disease has a more severe clinical course in healthcare workers.


Mild disease is defined as mild symptoms without pneumonia manifestations on imaging.10 Rehabilitation for mild disease can be managed in the outpatient setting using telemedicine.2 In mild disease, pulmonary rehabilitation may be considered and include education, airway clearance techniques, physical exercise, breathing exercises, activity guidance, and anxiety management.4 Details are summated in Table 1.

Proposed content for mild disease

In particular, adequate handling and disposal of corporal fluid should be practiced in home-based pulmonary rehabilitation. Patients should be instructed to cover nose and mouth with tissue when coughing or sneezing with the immediately disposal of the tissue. Expectorant hygiene into a closed container should be reinforced to prevent aerosolization of sputum. Hand hygiene with hand washing after having contact with respiratory secretions and contaminated objects/materials should be emphasized.

Patients should be educated on the clinical course of COVID-19 and with individualization based on patient comorbidities.11 The patient, including asymptomatic family members, may be counseled to wear masks3; SARS-CoV-2 has a high transmission rate and a long asymptomatic prodromal phase with a range of 2–14 days and a mean of 3–7 days.5 Mathematical modeling shows that mask use with 50% compliance during a viral outbreak can curb the spread with a 50% decrease in prevalence and 20% decrease in cumulative incidence.3

Breathing exercises may be used at this stage (Table 1). Diaphragmatic breathing involves coaching the patient to predominantly engage the diaphragm while minimizing the action of accessory muscles.9 Nasal inspiration should be encouraged to facilitate recruitment of the diaphragm and enhance humidification.7 Active abdominal muscle contraction should be used at the end of expiration to increase abdominal pressure and push diaphragm up to a more favorable length tension.8

Yoga and in particular Viniyoga coordinates breathing with arm lifts or body positioning during the inspiratory or expiratory phase. Pranayama, Tai chi,12 and singing also use timed breathing techniques.


Moderate to severe disease is defined as symptomatic patients with or approaching respiratory distress with respiratory rate more than 30 times per minute, oxygen saturation at rest of less than 93%, or Pao2/Fio2 of less than 300 mm Hg. These patients require hospitalization and monitoring.10

Pulmonary rehabilitation during acute management of COVID-19 should be considered when possible (Fig. 1) and is summarized in Table 2. In acute exacerbation of chronic lung conditions, pulmonary rehabilitation results in moderate to large effects on health-related quality of life and exercise capacity.13 Overall, pulmonary rehab in acute illness seems to be safe with no increased mortality13,14 and can be safely implemented for COVID-19.15

Suggested flowchart for rehabilitation interventions during acute hospitalization.
Proposed acute management

Early pulmonary rehabilitation and mobilization in the intensive care unit (ICU) may be approached with cautious consideration and should not occur at the expense of healthcare worker safety.16 SARS-CoV-2 aerosolizes during procedures and in ICU environments.17 To preserve personal protective equipment and given the questionable outcome of early mobilization in the ICU,6 early mobilization by additional rehabilitation staff is not recommended in the ICU and may be a consideration by dedicated ICU staff.2 Respiratory muscle weakness from diaphragm proteolysis may occur after prolonged mechanical ventilation,18 and inspiratory muscle training may occur during weaning trials with a skilled respiratory therapist.18,19

Initiation of pulmonary rehabilitation in the inpatient setting should occur with safety criteria in mind. Approximately 3%–5% of otherwise healthy patients can progress within 7–14 days of infection to severe or even critical conditions.11 Therefore, initial intensity of exercise should be graded and approached with caution and monitoring. Exclusion criteria include the following: (1) body temperature of greater than 38.0°C; (2) initial diagnosis time or symptom onset of 3 days or less; (3) initial onset of dyspnea of 3 days or less; (4) chest image progression within 24–48 hrs of more than 50%; (5) Spo2 of 90% or less; (6) blood pressure of less than 90/60 mm Hg or greater than 180/90 mm Hg15; (7) respiratory rate of greater than 40 times per minute; (8) heart rate of less than 40 beats per minute or greater than 120 beat per minute; (9) new onset of arrhythmia and myocardial ischemia; and (10) altered level of consciousness.

Physical exercise is a core component of pulmonary rehabilitation and may start with bed mobility in the very deconditioned patient to walking in the ambulatory patient.3 Rehabilitation intervention should target Spo2 of greater than 90% with titration of supplemental oxygen to maintain target saturation.3,4,11 Pause in activity should occur if Spo2 drops below target or a Borg Dyspnea Scale score of higher than 3 with consideration of breathing technique like pursed lip breathing with resumption of exercise intervention once Spo2 reaches target.11,20

Pursed lips breathing is performed by a nasal inspiration, followed by expiratory blowing against pursed lips to decrease airway collapse, reduce respiratory rate and dynamic hyperinflation during exercise training with the aim of an overall increase endurance.20 Oxygen supplementation has also been successfully used during exercise training to help unload the respiratory muscles.2,11

Pulmonary rehabilitation or breathing exercises should be stopped if Spo2 does not recover and the patient is unable to maintain a Borg Dyspnea Scale score of less than 4, with rest and oxygen supplementation. Rehabilitation exercises should also stop for chest pain, palpations, and dizziness. The Borg Scale is a validated and easy-to-use tool for patients to self-monitor respiratory effort with a close correlation between the magnitude of respiratory effort and the intensity of dyspnea.21

Active cycle of breathing techniques uses combinations and cycles of airway clearance techniques to ventilate obstructed lung segements.22 No specific technique has found to be superior to over others and should be based on training and expertise.23 Autogenic drainage is a common technique that uses a combination of the maneuvers to mobilize and centralize secretions with short breaths to collect secretions in peripheral airway, followed by normal breaths to collect secretions into the intermediate airway, and deep breaths and huff cough to expel secretions.24

Application of airway clearance techniques can significantly reduce the need for ventilatory support, days of mechanical ventilation, and hospitalization.7 Airway clearance techniques aim to help airway clearance by mobilizing mucus in a cephalad direction from the peripheral to upper airway, promoting the recruitment of lung volume, and eliminating mucus by cough or forced expectoration.10 Physical exercise is a cornerstone of pulmonary rehabilitation and has been shown to facilitate airway clearance.5 In acute phases, early mobilization and physical exercise are preferred and more effective than mucus clearance techniques, and mucus clearance techniques should not be used alone or take precedence over physical movement.9

Lung volume recruitment maneuvers include air stacking and glottis holding. Air stacking involves delivery of air via Ambu bag.25 Glossopharyngeal breathing is a form of positive pressure breathing technique that can be used to assist failing respiratory muscles and increase tidal volumes. It involves successive inhale of boluses of air and pushing them into the lungs.26 The 3-sec breath hold is a method of ventilating obstructed lung segments. A pause for 3 secs allows for Pendelluft flow where air moves from unobstructed regions to the obstructed regions of the lung.27

Forced expiration maneuvers like the huff cough can be used to propel secretions. A huff cough is performed with an open glottis where equal pressure point dynamic compression of the airways creates an increase in the linear velocity of the expiratory airflow and propels secretions. Initiating a forced expiration at a low lung volume shifts the equal pressure point to the periphery and small airways. A forced expiration from a high lung volume will move the equal pressure point centrally toward the large central airway.28

Posture plays an important role in respiratory function,12 and patients can be encouraged to engage in erect head and neck positioning during respiratory treatment and at all times when possible. External vibration if available may be applied with oscillation frequencies less than 17 Hz to improve mucociliary clearance.24

Positioning is effective, simple, and easy to accomplish.29 Positioning may be preferable over other techniques such as postural drainage given the pathophysiology of COVID-19 and the observed V/Q mismatch.29,30 Sitting and standing are the preferred positions in noncritically ill patients to maximize lung function including forced vital capacity, increase lung compliance and elastic recoil, and shift mediastinal structures, and provide mechanical advantage in forced expiration.13,14,31

Targeted positioning may be used to enhance ventilation, perfusion, oxygenation, and mobilization of secretions in specific lung regions of consolidations through gravity.21 Perfusion is greater to the dependent lung segments in all positions.32 Preferential ventilation changes based on position. Two minutes in each position while engaging in breathing exercises may be sufficient to ventilate/perfuse targeted lung segments.32

Anecdotal evidence in hospitals suggesting prone positioning during acute care of COVID-19 patient has been beneficial. If possible, we recommend time in all positions including side lying, upright, supine, and prone and guided by imaging findings when possible. Targeted positions may be determined by the location of consolidations seen on imaging or found on examination.11

In the upright position, ventilation preferentially occurs in the mid and lower lobes with perfusion greatest in the lower lobes.33 Patients may rest in a supine position occasionally to aid in diffusing capacity for carbon monoxide (DLCO). The DLCO increases in the supine position in healthy subjects.34 Supine position also preferentially ventilates the upper lobes.33

In adults side-lying position preferentially ventilates the dependent lung by maximizing the length-tension ratio in the dependent hemidiaphragm and negative pleural pressure.35 In young children younger than 12 yrs, side-lying position preferentially ventilates the nondependent lung and closing of airway in depend regions. Side lying may be a good position during administration of inhaled drug with improved deposition by 13% to the dependent upper lobe.32

Prone positioning for 2-min duration may aid in ventilation to dorsal lung through reduction in lung compression by the heart in the semi-prone position because of ventral displacement of the heart24 with increases in end-expiratory transpulmonary pressure and expiratory reserve volume,25 more homogenous lung inflation from dorsal to ventral and improvement in oxygenation.26 Prone positioning has been used in the ICU to improve gas exchange in ARDS and improve Pa/Fio2 in patients on mechanical ventilation and reduces cardiovascular comorbidities.36

Patients may be encouraged to engage in routine stretching 3 times a day. Stretching has been shown to increase compliance by as much as 50 ml. Stretches should include neck, upper chest, pectoralis major, lateral chest stretches,37 and flexion and extension to mobilize the facet joints. The dorsal chest wall has been shown to be less compliant in patients with ARDS.38

Osteopathic manipulation, if appropriate, may be helpful and should address autonomics, lymph drainage, and rib cage mobility.39 The patient may also engage in modified segmental breathing where the patient applies pressure to their own thoracic cage to resist respiratory excursion in one area of the thoracic cavity and to facilitate the expansion of adjacent regions of the thoracic cavity that may have decreased ventilation and mobility.40

Education regarding proper nutrition is particularly important in COVID-19 as studies from Western countries are showing that obesity to be a significant risk factor for severity of disease with at least two-third of ICU patients having overweight BMI.41 In obesity, lung function is also impaired.42

The same strategies may be applied to patients recovering from ICU level care. In these patients, a focus on breathing exercises (Table 3) and bed mobility may be the initial intervention given the deconditioning that occurs in ICU. Bed mobility exercises include ankle pumps, sliding legs into flexion/extension, overhead arm stretches, and sit to stand at bedside. In addition, respiratory muscle weakness from diaphragm proteolysis may be suspected in those patients with prolonged mechanical ventilation.18 Inspiratory and expiratory muscle training can be implemented in these patients starting with incentive spirometry and progressing to inspiratory muscle training devices if available.18,19

Airway clearance techniques


Appropriateness for inpatient acute rehabilitation should be individualized to the patient and the facility with ongoing American Academy of Physical Medicine and Rehabilitation guidance.2,43 Outpatient posthospitalization pulmonary rehabilitation may be considered in all patients hospitalized with COVID-19.44 Patient selection criteria will have to be developed in the coming months after the pandemic. Quadriceps weakness and impaired exercise capacity may be predictors of good candidates for pulmonary rehabilitation.45 Occupational and physical therapy may also be considered in those with residual functional deficits associated with prolonged hospitalization.

Routine monitoring with chest x-ray and pulmonary function tests may be considered in the outpatient setting particularly within 6 mos of infection and for severe and critical patients. Pulmonary fibrosis may occur in COVID-19. In SARS-CoV in 2003, pulmonary fibrosis was seen to develop in 45% of patients (diagnosed by x-ray and CT scan) 1 mo after infection, 30%–36% 3–6 mos after infection,46 and 28% 1 yr after infection.46 After SARS-CoV infection, severity of fibrosis and disability correlated with the severity and duration of illness.47,48 Improvement in lung function in SARS-CoV patients plateaued at 6 mos with continued disability particularly in DLCO 2 yrs after infection.49

Pulmonary rehabilitation in the postacute period may work toward improvement in exercise capacity. In patients with interstitial lung disease, exertional desaturation is a key feature and is often more severe than that seen in other pulmonary conditions.50 Interstitial lung disease is associated with reduced ventilatory capacity and tissue oxygenation with premature onset of metabolic acidosis with dyspnea and lower limb discomfort/fatigue during submaximal exercise.22,51 Pulmonary hypertension also be present and decrease exercise capacity.52 Supplemental oxygen may be needed to facilitate oxygenation of tissue and enhance exercise capacity with target Spo2 from 85% to 90%.44


Physical medicine and rehabilitation physicians and rehabilitation may play a pivotal role in restoring function and limiting disability this pandemic. Physical medicine and rehabilitation interventions and pulmonary rehabilitation give us additional tools in the fight against COVID-19 and may include nutrition, airway, posture, clearance technique, oxygen supplementation, breathing exercises, stretching, manual therapy, and physical activity. In the months to years after this pandemic, the burden of disease may be large and PM&R will play a crucial role in the rehabilitation of patients with disability in relation to COVID-19.


1. Janssens JP, Chappuis-Gisin É, Maragkoudakis C, et al.: Pulmonary rehabilitation in respiratory disorders other than COPD: an individualized approach [in French]. Rev Med Suisse 2018;14:2054–7
2. Lim PA, Ng YS, Tay BK: Impact of a viral respiratory epidemic on the practice of medicine and rehabilitation: severe acute respiratory syndrome. Arch Phys Med Rehabil 2004;85:1365–70
3. Spruit MA, Singh SJ, Garvey C, et al.: An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med 2013;188:e13–64
4. Chinese Association of Rehabilitation Medicine; Respiratory rehabilitation committee of Chinese Association of Rehabilitation Medicine; Cardiopulmonary rehabilitation Group of Chinese Society of Physical Medicine and Rehabilitation: Recommendations for respiratory rehabilitation of coronavirus disease 2019 in adult [in Chinese]. Zhonghua Jie He He Hu Xi Za Zhi 2020;43:308–14
5. Guo YR, Cao QD, Hong ZS, et al.: The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res 2020;7:11
6. Alison JA, McKeough ZJ, Johnston K, et al.; Lung Foundation Australia and the Thoracic Society of Australia and New Zealand: Australian and New Zealand pulmonary rehabilitation guidelines. Respirology 2017;22:800–19
7. Elad D, Wolf M, Keck T: Air-conditioning in the human nasal cavity. Respir Physiol Neurobiol 2008;163(1–3):121–7
8. Casciari RJ, Fairshter RD, Harrison A, et al.: Effects of breathing retraining in patients with chronic obstructive pulmonary disease. Chest 1981;79:393–8
9. Gosselink R: Breathing techniques in patients with chronic obstructive pulmonary disease (COPD). Chron Respir Dis 2004;1:163–72
10. Lin L, Li TS: Interpretation of “Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 5)” [in Chinese]. Zhonghua Yi Xue Za Zhi 2020;100:E001
11. Rodriguez-Morales AJ, Cardona-Ospina JA, Gutiérrez-Ocampo E, et al.; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19): Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis 2020;34:101623
12. Ngai SP, Jones AY, Tam WW: Tai chi for chronic obstructive pulmonary disease (COPD). Cochrane Database Syst Rev 2016:CD009953
13. Jones SE, Barker RE, Nolan CM, et al.: Pulmonary rehabilitation in patients with an acute exacerbation of chronic obstructive pulmonary disease. J Thorac Dis 2018;10(S12):S1390–9
14. Puhan MA, Gimeno-Santos E, Cates CJ, et al.: Pulmonary rehabilitation following exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2016;12:CD005305
15. Yang F, Liu N, Hu JY, et al.: Pulmonary rehabilitation guidelines in the principle of 4S for patients infected with 2019 novel coronavirus (2019-nCoV) [in Chinese]. Zhonghua Jie He He Hu Xi Za Zhi 2020;43:180–2
16. Liu W, Mu X, Wang X, et al.: Effects of comprehensive pulmonary rehabilitation therapy on pulmonary functions and blood gas indexes of patients with severe pneumonia. Exp Ther Med 2018;16:1953–7
17. Wax RS, Christian MD: Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients. Can J Anaesth 2020;67:568–76
18. Bissett B, Gosselink R, van Haren FMP: Respiratory muscle rehabilitation in patients with prolonged mechanical ventilation: a targeted approach. Crit Care 2020;24:103
19. Paiva DN, Assmann LB, Bordin DF, et al.: Inspiratory muscle training with threshold or incentive spirometry: which is the most effective? Rev Port Pneumol (2006) 2015;21:76–81
20. Mayer AF, Karloh M, Dos Santos K, et al.: Effects of acute use of pursed-lips breathing during exercise in patients with COPD: a systematic review and meta-analysis. Physiotherapy 2018;104:9–17
21. Cullen DL, Rodak B: Clinical utility of measures of breathlessness. Respir Care 2002;47:986–93
22. McKoy NA, Saldanha IJ, Odelola OA, et al.: Active cycle of breathing technique for cystic fibrosis. Cochrane Database Syst Rev 2012;12:CD007862
23. Wilson LM, Morrison L, Robinson KA: Airway clearance techniques for cystic fibrosis: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 2019;1:CD011231
24. McCormack P, Burnham P, Southern KW: Autogenic drainage for airway clearance in cystic fibrosis. Cochrane Database Syst Rev 2017;10:CD009595
25. Kang SW, Bach JR: Maximum insufflation capacity: vital capacity and cough flows in neuromuscular disease. Am J Phys Med Rehabil 2000;79:222–7
26. Maltais F: Glossopharyngeal breathing. Am J Respir Crit Care Med 2011;184:381
27. Crawford AB, Cotton DJ, Paiva M, et al.: Effect of airway closure on ventilation distribution. J Appl Physiol 1989;66:2511–5
28. McIlwaine M, Bradley J, Elborn JS, et al.: Personalising airway clearance in chronic lung disease. Eur Respir Rev 2017;26:160086
29. Fink JB: Positioning versus postural drainage. Respir Care 2002;47:769–77
30. Gattinoni L, Coppola S, Cressoni M, et al.: Covid-19 does not lead to a “typical” acute respiratory distress syndrome. Am J Respir Crit Care Med 2020;201:1299–300
31. Manning F, Dean E, Ross J, et al.: Effects of side lying on lung function in older individuals. Phys Ther 1999;79:456–66
32. Dentice RL, Elkins MR, Dwyer GM, et al.: The use of an alternate side lying positioning strategy during inhalation therapy does not prolong nebulisation time in adults with cystic fibrosis: a randomised crossover trial. BMC Pulm Med 2018;18:3
33. Bailey DL, Farrow CE, Lau EM: V/Q SPECT-normal values for lobar function and comparison with CT volumes. Semin Nucl Med 2019;49:58–61
34. Katz S, Arish N, Rokach A, et al.: The effect of body position on pulmonary function: a systematic review. BMC Pulm Med 2018;18:159
35. Bhuyan U, Peters AM, Gordon I, et al.: Effects of posture on the distribution of pulmonary ventilation and perfusion in children and adults. Thorax 1989;44:480–4
36. Guérin C, Reignier J, Richard J-C, et al.: Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013;368:2159–68
37. Rattes C, Campos SL, Morais C, et al.: Respiratory muscles stretching acutely increases expansion in hemiparetic chest wall. Respir Physiol Neurobiol 2018;254:16–22
38. Pelosi P, D’Andrea L, Vitale G, et al.: Vertical gradient of regional lung inflation in adult respiratory distress syndrome. Am J Respir Crit Care Med 1994;149:8–13
39. Tang X, Du RH, Wang R, et al.: Comparison of hospitalized patients with ARDS caused by COVID-19 and H1N1. Chest 2020;158:195–205
40. Harmony WN: Segmental breathing. Phys Ther Rev 1956;36:106–7
41. Intensive Care National Audit & Research Centre: ICNARC Report on COVID-19 in Critical Care. Intensive Care National Audit & Research Centre. Available at: Published April 10, 2020. Accessed April 15, 2020
42. Chlif M, Temfemo A, Keochkerian D, et al.: Advanced mechanical ventilatory constraints during incremental exercise in class III obese male subjects. Respir Care 2015;60:549–60
43. AAPM&R Board of Governors: AAPM&R Position Statement on the Necessity and Preservation of Personal Protective Equipment. Available at: Published March 30, 2020. Accessed April 15, 2020
44. Dowman L, Hill CJ, Holland AE: Pulmonary rehabilitation for interstitial lung disease. Cochrane Database Syst Rev 2014;10:CD006322
45. Burtin C, Saey D, Saglam M, et al.: Effectiveness of exercise training in patients with COPD: the role of muscle fatigue. Eur Respir J 2012;40:338–44
46. Hui DS, Joynt GM, Wong KT, et al.: Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax 2005;60:401–9
47. Xie L, Liu Y, Xiao Y, et al.: Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge. Chest 2005;127:2119–24
48. Venkataraman T, Frieman MB: The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis. Antiviral Res 2017;143:142–50
49. Ngai JC, Ko FW, Ng SS, et al.: The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status. Respirology 2010;15:543–50
50. Jenkins S, Čečins N: Six-minute walk test: observed adverse events and oxygen desaturation in a large cohort of patients with chronic lung disease. Intern Med J 2011;41:416–22
51. Vogiatzis I, Zakynthinos S: Factors limiting exercise tolerance in chronic lung diseases. Compr Physiol 2012;2:1779–817
52. Boutou AK, Pitsiou GG, Trigonis I, et al.: Exercise capacity in idiopathic pulmonary fibrosis: the effect of pulmonary hypertension. Respirology 2011;16:451–8

Pulmonary Rehabilitation; Inpatient Rehabilitation; Multidisciplinary/Interdisciplinary Rehabilitation; COVID-19

Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.