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Single Intra-articular Platelet-Rich Plasma Versus Corticosteroid Injections in the Treatment of Adhesive Capsulitis of the Shoulder

A Cohort Study

Barman, Apurba MD; Mukherjee, Somnath MD; Sahoo, Jagannatha DNB; Maiti, Rituparna MD; Rao, Parnandi Bhaskar MD; Sinha, Mithilesh Kumar MS; Sahoo, Dibyajyoti MD; Tripathy, Sujit Kumar MS; Patro, Binod Kumar MD; Bag, Nerbadyswari Deep MD

American Journal of Physical Medicine & Rehabilitation: July 2019 - Volume 98 - Issue 7 - p 549–557
doi: 10.1097/PHM.0000000000001144
Original Research Articles
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Objective The aim of the study was to compare the effects of single intra-articular platelet-rich plasma (PRP) and corticosteroid (CS) injections in patients with adhesive capsulitis of the shoulder.

Design Patients aged 18–70 yrs of either sex, diagnosed with adhesive capsulitis of shoulder, with less than 6-mo duration, were included. In intra-articular corticosteroid (IA-CS, control) group, 30 patients received a single injection (4 ml) of IA-CS and in IA-PRP (test) group, 30 patients received single IA-PRP injection (4 ml) into the glenohumeral joint under ultrasound guidance. All patients were prospectively followed for 12 wks.

Results Twenty-eight patients in IA-PRP group and 27 in IA-CS group finished the entire 12-wk study period. At 12 wks, decrements in visual analog scale and total shoulder pain and disability index scores, in IA-PRP group, were 58.4 and 55.1, compared with 48.7 and 45.8 in IA-CS group. In range of movement, IA-PRP group showed significant improvement in passive abduction (−50.4 vs. −39.4), internal (−36.8 vs. −25.8), and external rotations (−35.4 vs. −25.9) compared with IA-CS group, respectively. No major complications were observed in any patients.

Conclusions At 12-wk follow-up, a single dose of IA-PRP injection was found to be more effective than an IA-CS injection, in terms of improving pain, disability, and shoulder range of movement in patients with adhesive capsulitis of the shoulder.

From the Departments of Physical Medicine and Rehabilitation (AB, JS), Transfusion Medicine (SM, DS), Pharmacology (RM), Anesthesia and Intensive Care (PBR), General Surgery (MKS), Orthopaedics (SKT), Community and Family Medicine (BKP), and Radiodiagnosis (NDB), All India Institute of Medical Sciences, Bhubaneswar, India.

All correspondence should be addressed to: Apurba Barman, MD, Department of PM&R, All India Institute of Medical Sciences, Bhubaneswar, Patrapada, Dumuduma, Bhubaneswar, Odisha, India 751019.

The study was supported by Institutional Intramural Research Grant, All India Institute of Medical Sciences, Bhubaneswar, India (Grant Number IMF 21/2016).

Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.

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Online date: January 23, 2019

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