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The effect of CT-guided botulinum toxin injection on cervical dystonia, confirmed by nine-month follow-up using 18F-FDG PET/CT

A case report

Lee, Seung Ah1; Choi, Ja-Young2; Oh, Byung-Mo3

American Journal of Physical Medicine & Rehabilitation: February 7, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/PHM.0000000000001156
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Although accurate targeting of the causative muscles is of paramount importance in the treatment of focal dystonia, this is often challenging due to distortion of the affected anatomical structures and difficulty in proper positioning of injections. We report a case of idiopathic cervical dystonia that was treated by CT-guided injection of botulinum toxin (BTX) into multiple deep muscles.

Based on clinical presentation of combined torticollis and retrocollis, and needle electromyography (EMG) results, BTX was injected under EMG guidance. This treatment resulted in no improvement.

Subsequently, target muscles were identified using fludeoxyglucose (18F-FDG) fusion positron emission tomography/computed tomography (18F-FDG PET/CT). BTX was injected into the hypermetabolic muscles. This injection successfully relieved the symptoms, and nine months of follow-up using PET/CT confirmed that hypermetabolic muscles had been normalized. This case indicated that CT guidance may facilitate accurate targeting of BTX injection. To the authors’ knowledge, this is the first case reporting a positive effect of BTX on cervical dystonia symptoms that lasted nine months, confirmed by follow-up PET/CT.

1 Department of Physical Medicine & Rehabilitation, Kyung Hee University College of Medicine, Seoul, Republic of Korea

2 Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea

3 Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea

Address for Correspondence: Byung-Mo Oh, MD, PhD, Department of Rehabilitation Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea. Fax:+82-2-2072-2561. Phone:+82-10-9944-4481. E-mail: keepwiz@gmail.com

Disclosure: The authors have no conflicts of interest, provided funding, financial benefits, and details of any previoius presentation of this report

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