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TIME EFFECTOF INTRA-ARTICULAR INJECTION WITH TRIAMCINOLONE HEXACETONIDE AND ITS CORRELATIONS

A CASE – CONTROL PROSPECTIVE 12 MONTH STUDY

Rocha, Roberta Hora MD; Natour, Jamil MD, PhD; dos Santos, Rita M. RN; Furtado, Rita Nely V. MD, PhD

American Journal of Physical Medicine & Rehabilitation: May 3, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/PHM.0000000000001217
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Objective To assess the time effect of intra-articular (IA) injection with triamcinolone hexacetonide (TH) in rheumatic patients.

Design A prospective case-control study with patients submitted to one IA injection with TH. Patients were followed monthly (12 months) for pain and swelling.

Results 262 joints were assessed in 158 patients with mean age of 60 (±13.7) years. Remission were observed at 3, 6 and 12 months in 142 (54.19%), 111 (42.36%) and 105 (40.07%) joints, respectively.The mean time effect were 8 (±4.0) months; 8.4 (±3.9) for rheumatoid arthritis (RA) patients and 6.9 (±4.0) for osteoarthritis patients (p=0.012); and 10.4 (±2.7) months for small; 7.7 (±4.1) for medium and 6.8(±4.0) for large joints. The joints were divided into two groups: long-term group (LTG- time effect of IA injection longer than six months) and short-term group (STG).Variables associated (p <0.05) with LTG: RA, small and medium-sized joints, female gender, lower pain and swelling VAS scores and use of leflunomide. Variables associated with STG: receiving only one IA injection, hypertension, diabetes mellitus, biological therapy.

Conclusion The time effect of IA injection with TH was 8.0 (±4.0) months. The associated predictors were RA, small and medium-sized joints, lower pain/swelling VAS scores, and use of leflunomide.

Rheumatology Division - Universidade Federal de São Paulo - Escola Paulista de Medicina - Sao Paulo, SP, Brazil.

Financial information: none

Corresponding Author: Rita Nely Vilar Furtado, Universidade Federal de São Paulo, Rua Botucatu, 740 – 04023-900, São Paulo/SP – Brazil, Telephone contact/ Fax: 55-11-55764239, Email: rvfurtado@hotmail.com

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