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Functional capacity change impacts the quality of life of hospitalized patients undergoing hematopoietic stem cell transplantation

de Almeida, Leonardo Barbosa, M.S.1; Mira, Pedro Augusto de Carvalho, Ph.D.1; Fioritto, Aline Priori2; Malaguti, Carla, Ph.D.2; Neto, Abrahão Elias Hallack, Ph.D.3; Trevizan, Patrícia Fernandes, Ph.D.1; Laterza, Mateus Camaroti, Ph.D.1,2; Martinez, Daniel Godoy, Ph.D.1,2

American Journal of Physical Medicine & Rehabilitation: January 3, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/PHM.0000000000001125
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Objective To compare the quality of life of patients undergoing hematopoietic stem cell transplantation (HSCT) who improved their functional capacity during hospitalization (IFC group) with that of patients who maintained or decreased functional capacity during hospitalization (DFC group).

Design This observational, longitudinal study included 27 hospitalized patients undergoing HSCT. Patients were divided into IFC (16 patients) and DFC (11 patients). Functional capacity (6-minute Step Test), peripheral muscle strength (Sit-to-Stand Test and Handgrip Strength), and quality of life (EORTC-QLQ-C30) were assessed at admission and at hospital discharge.

Results IFC patients had increased functional capacity and peripheral muscle strength of the lower and upper limbs at hospital discharge (P < 0.01, <0.01, and 0.02, respectively). The patients in the IFC group demonstrated an increase in global health and reduced symptoms at discharge (P = 0.02 and 0.03, respectively). No significant differences were observed between groups in the functional domain.

Conclusion Patients undergoing HSCT who have improved functional capacity at discharge, also experience an improved quality of life, with no such improvement noted among patients who have stable or reduced functional capacity. We recommend that the treatment protocol for hospitalized patients undergoing HSCT include an exercise program aimed at improving functional capacity.

1 Cardiovascular Research Unit and Exercise Physiology, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

2 Master´s Program on Rehabilitation Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

3 Department of Hematology, Hemotherapy and Bone Marrow Transplantation, Federal University of Juiz de Fora, Juiz de Fora, Brazil. Department of Clinical Medical, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Corresponding author: Leonardo Barbosa de Almeida, M.S., Federal University of Juiz de Fora, Cardiovascular Research Unit and Exercise Physiology, José Lourenço Kelmer, s/n, Martelos, 36036-900, Juiz de Fora, Brazil, Fax: +32/2102 3291 / email: almeidalb@hotmail.com

Author disclosures: All authors report no conflict of interests and this study did not receive financial support. This manuscript has not been published or presented elsewhere in part or in entirety and is not under consideration by another journal

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