The purpose of this study was to test whether fractionated irradiation in photobiomodulation therapy enhances short-term recovery in patients with moderate severity ankle sprain.
Nineteen patients were randomly assigned to 1 of 2 groups: one group receiving photobiomodulation therapy combined with the standard rest, icing, compression, elevation treatment or a group receiving only standard treatment. Group 1 patients were irradiated using a laser system (635 nm, 15 mW) according to a double-fractionated irradiation scheme consisting of two sessions (4.5 J/cm2 and 9 J/cm2) separated by a 30 min time interval. Short-term outcomes (reflectance, pain and clinical outcomes) were assessed at baseline, 10 days and 6 weeks after treatment.
Reflectance data analysis showed significant changes in group 1 (p = 0.027). There was also an ankle function score improvement more in group 1 than in group 2, with a significant short-term effect (p = 0.011) but without significant long-term effects (p = 0.178). Compared with group 2, group 1 had an immediate effect on pain reduction, but no long-term effect (p = 0.074).
Combined with standard treatment, fractionated irradiation photobiomodulation therapy has been shown to have favorable short-term effects on the recovery of patients with ankle sprains, but its long-term effects should be improved.
1National Institute of Research and Development for Optoelectronics – INOE 2000, Magurele, Romania
2Carol Davila University of Medicine and Pharmacy Bucharest, Romania
3Emergency University Hospital, Bucharest, Romania
4National Institute for Infectious Diseases Prof Dr Matei Bals
5National Institute of Rehabilitation, Physical Medicine and Balneoclimatology, Bucharest, Romania
Corresponding author:Mihaela Antonina Calin, PhD, National Institute of Research and Development for Optoelectronics INOE 2000, 409 Atomistilor Street, P.O. BOX MG5, Magurele, Ilfov, 077125, Romania, Phone/fax: + (4021) 457.45.22, e-mail: email@example.com; firstname.lastname@example.org
Conflict of interest statement: The authors declare that they have no conflict of interest.
Funding information: This work was financed by the Romanian Ministry of Research and Innovation by means of the Research Program No. PN 33N/16.03.2018.