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Fractionated irradiation in photobiomodulation therapy of ankle sprain

Calin, Mihaela Antonina1; Badila, Adrian2,3; Hristea, Adriana2,4; Manea, Dragos1; Savastru, Roxana1; Nica, Adriana Sarah2,5

American Journal of Physical Medicine & Rehabilitation: March 12, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/PHM.0000000000001178
Research Article: PDF Only

Objective The purpose of this study was to test whether fractionated irradiation in photobiomodulation therapy enhances short-term recovery in patients with moderate severity ankle sprain.

Design Nineteen patients were randomly assigned to 1 of 2 groups: one group receiving photobiomodulation therapy combined with the standard rest, icing, compression, elevation treatment or a group receiving only standard treatment. Group 1 patients were irradiated using a laser system (635 nm, 15 mW) according to a double-fractionated irradiation scheme consisting of two sessions (4.5 J/cm2 and 9 J/cm2) separated by a 30 min time interval. Short-term outcomes (reflectance, pain and clinical outcomes) were assessed at baseline, 10 days and 6 weeks after treatment.

Results Reflectance data analysis showed significant changes in group 1 (p = 0.027). There was also an ankle function score improvement more in group 1 than in group 2, with a significant short-term effect (p = 0.011) but without significant long-term effects (p = 0.178). Compared with group 2, group 1 had an immediate effect on pain reduction, but no long-term effect (p = 0.074).

Conclusions Combined with standard treatment, fractionated irradiation photobiomodulation therapy has been shown to have favorable short-term effects on the recovery of patients with ankle sprains, but its long-term effects should be improved.

1National Institute of Research and Development for Optoelectronics – INOE 2000, Magurele, Romania

2Carol Davila University of Medicine and Pharmacy Bucharest, Romania

3Emergency University Hospital, Bucharest, Romania

4National Institute for Infectious Diseases Prof Dr Matei Bals

5National Institute of Rehabilitation, Physical Medicine and Balneoclimatology, Bucharest, Romania

Corresponding author:Mihaela Antonina Calin, PhD, National Institute of Research and Development for Optoelectronics INOE 2000, 409 Atomistilor Street, P.O. BOX MG5, Magurele, Ilfov, 077125, Romania, Phone/fax: + (4021) 457.45.22, e-mail:;

Conflict of interest statement: The authors declare that they have no conflict of interest.

Funding information: This work was financed by the Romanian Ministry of Research and Innovation by means of the Research Program No. PN 33N/16.03.2018.

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