Special Research SectionConducting a Systematic Review and Meta-analysis in RehabilitationFurlan, Andrea D. MD, PhD; Irvin, Emma BA Author Information From the Institute for Work & Health, Toronto, Ontario, Canada (ADF, EI); Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada (ADF); and Division of Physical Medicine & Rehabilitation, Department of Medicine, University of Toronto, Toronto, Ontario, Canada (ADF). All correspondence should be addressed to: Andrea D. Furlan, MD, PhD, 400 University Ave, Suite 1800, Toronto, ON M5G 1S5, Canada. For the special issue of the American Journal of Physical Medicine and Rehabilitation. ADF and EI participated in the conception of this manuscript. EI conducted the searches and screened the results. ADF and EI drafted the article and both made critical revisions of the final article. ADF and EI approved the final version of the article. Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article. American Journal of Physical Medicine & Rehabilitation 101(10):p 965-974, October 2022. | DOI: 10.1097/PHM.0000000000001933 Buy Metrics Abstract Systematic reviews are reviews of the literature using a step-by-step approach in a systematic way. Meta-analyses are systematic reviews that use statistical methods to combine the included studies to generate an effect estimate. In this article, we summarize 10 steps for conducting systematic reviews and meta-analyses in the field of rehabilitation medicine: protocol, review team and funding, objectives and research question, literature search, study selection, risk of bias, data extraction, data analysis, reporting of results and conclusions, and publication and dissemination. There are currently 64,958 trials that contain the word “rehabilitation” in CENTRAL (the database of clinical trials in the Cochrane Library), only 1246 reviews, and 237 protocols. There is an urgent need for rehabilitation physicians to engage and conduct systematic reviews and meta-analysis of a variety of rehabilitation interventions. Systematic reviews have become the foundation of clinical practice guidelines, health technology assessments, formulary inclusion decisions and to guide funding additional research in that area. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.