From the Departments of Orthopaedic Surgery (YW, RJT, SEG, LY, SSS, RLM, LQ, YZ) and Physical Medicine & Rehabilitation (ZT, RLM, YZ), Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (YW); Translational Musculoskeletal Research Center (TMRC), Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania (SEG, RLM, YZ); and Department of Orthopaedics/Sports Medicine and Joint Surgery, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, China (LY).
All correspondence should be addressed to: Yejia Zhang, MD, PhD, Department of Physical Medicine & Rehabilitation, Perelman School of Medicine, University of Pennsylvania, 1800 Lombard St, 1st Floor, Philadelphia, PA 19146.
This study was supported in part by research grants to YZ from the Department of Veterans Affairs Healthcare Network, a Penn Center for Musculoskeletal Disorders (PCMD) pilot grant (P30-AR050950-10 Pilot), and a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, R21 AR071623). The biomechanics and histology core facilities have been supported by a grant to the PCMD (P30AR069619). This work was also supported in part by research grants to LQ from the NIH (NIAMS R01AR066098 and R01DK095803).
All animal use in this study was reviewed and approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Pennsylvania, Philadelphia, PA. All authors approved the final version of the manuscript submitted.
Yulong Wei, Robert J. Tower, and Lutian Yao are in training.
Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.
