Case ReportsDorsal Root Ganglion Stimulation for Treatment of Chemotherapy-Induced NeuropathyGrabnar, Maria MD; Kim, Chong MDAuthor Information From the Case Western Reserve University/MetroHealth, Cleveland, Ohio. All correspondence should be addressed to: Chong Kim, MD, Case Western Reserve University/MetroHealth, 2500 MetroHealth Dr, Cleveland, OH 44109. Maria Grabnar is in training. Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.ajpmr.com). American Journal of Physical Medicine & Rehabilitation: April 2021 - Volume 100 - Issue 4 - p e52-e54 doi: 10.1097/PHM.0000000000001542 Buy SDC Metrics Abstract Chemotherapy-induced neuropathy has limited treatment options, and conventional medications used to treat neuropathic pain often do not provide adequate pain relief for patients with a history of cancer. Neuromodulation such as dorsal root ganglion stimulation remains a treatment that has been studied for chronic painful conditions such as low back pain, pelvic pain, complex regional pain syndrome, and phantom limb pain. Dorsal root ganglion stimulation has been presented for treatment of chemotherapy-induced neuropathy, but with limited duration of follow-up. We present a case of pain resolution after placement of a dorsal root ganglion stimulation for persistent chemotherapy-induced neuropathy. Our patient developed burning pain and allodynia in both feet 3 mos into her chemotherapy regimen, with worsened symptoms after cessation of chemotherapy. After failure of conservative pharmacotherapies, a 7-day dorsal root ganglion stimulation trial was implanted, resulting in 100% pain relief. A dorsal root ganglion stimulation was then implanted permanently, and our patient reported continued resolution of symptoms at evaluation 3 yrs after placement. To the author’s knowledge, this is the first case of sustained relief with dorsal root ganglion stimulation placement for chemotherapy-induced neuropathy and presents a treatment option that warrants further investigation. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.