Case ReportsCompensation of Ipsilateral Motor and Sensory Functions by Contralateral Uncrossed Pathway in a Stroke Patient With Half BrainShi, Yu MMed; Wan, Chunxiao MD, PhDAuthor Information From the Department of Physical and Rehabilitation Medicine, Tianjin Medical University General Hospital, Tianjin, China. All correspondence should be addressed to: Chunxiao Wan, MD, PhD, Department of Physical and Rehabilitation Medicine, Tianjin Medical University General Hospital, No. 154, Anshan Rd, Heping District, Tianjin, China. Yu Shi is in training. Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.ajpmr.com). American Journal of Physical Medicine & Rehabilitation: January 2021 - Volume 100 - Issue 1 - p e4-e8 doi: 10.1097/PHM.0000000000001432 Buy SDC Metrics Abstract This study reports a case of motor and sensory function recovery after massive left cerebral infarction in a young man, along with preserved function of the injured hemisphere. He received early rehabilitation therapy in a nerval care unit within 1 wk of surgery, and the rehabilitation lasted for more than 3 yrs. When he gradually recovered from coma, his motor, sensory, and speech functions improved significantly. Two years later, he was able to live independently and returned to work. The findings of functional magnetic resonance imaging, diffusion tensor imaging, somatosensory evoked potential, and motor evoked potential confirmed that there was a strong connection between his right brain and the right limbs. Thus, early rehabilitation is a promising approach for restoring motor and sensory function after massive brain injury or extensive brain tissue damage. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.