Case ReportImproved Mobility, Cognition, and Disease Severity in Corticobasal Degeneration of an African American Man After 12 Weeks of Adapted Tango A Case StudySilverstein, Hayley A. BA; Hart, Ariel R. BA; Bozorg, Ariyana MS; Hackney, Madeleine E. PhDAuthor Information From the Division of General Medicine and Geriatrics, Department of Medicine, School of Medicine, Emory University, Atlanta, Georgia (HAS, ARH, MEH); and Atlanta Veterans Affairs Rehabilitation R&D Center for Visual and Neurocognitive Rehabilitation, Decatur, Georgia (AB, MEH). All correspondence should be addressed to: Hayley A. Silverstein, BA, Emory University School of Medicine, Division of General Medicine and Geriatrics, 1841 Clifton Rd, Atlanta, GA 30329. The Department of Veterans Affairs R&D Service Career Development Award N0780W supported this work and ME Hackney. The Emory Center for Health in Aging supported the study. This study was also supported by National Center for Advancing Translational Sciences, National Institutes of Health Award UL1TR000454. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This research was previously presented as a poster at Emory University's Department of Medicine Day of Research on October 8, 2016 at Emory University, Atlanta, GA. Conflict of Interest: There are no apparent conflicts of interest in terms of honoraria received, speaker forums, consultant roles, stocks, royalties, expert testimony, board memberships, patents or personal relationships of any of the authors. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s Web site (www.ajpmr.com). Online date: February 20, 2019 American Journal of Physical Medicine & Rehabilitation: February 2020 - Volume 99 - Issue 2 - p e21-e27 doi: 10.1097/PHM.0000000000001165 Buy SDC Metrics Abstract Corticobasal degeneration (CBD) has no available treatment to slow disease progression and generally resists drug therapy. Corticobasal degeneration has symptoms and decreased quality of life similar to Parkinson disease. Adapted Tango, a successful rehabilitation for Parkinson, may address CBD. A 63-yr-old African American man with CBD (alias: YD; CBD duration = 2 yrs) was evaluated for motor, cognitive, and psychosocial function before, immediately after, 1 mo after, and 6 mos after 12 wks of 20, biweekly 90-min adapted-tango lessons. After intervention, disease-related motor symptoms improved and YD reported fewer problems in nonmotor experiences of daily living, which include mood, cognition, pain, fatigue, etc. Motor symptoms remained above baseline at 6-mo posttest. YD's balance confidence improved after intervention but declined below baseline at 6-mo posttest. Quality of life was maintained despite worsened depression. YD improved or maintained executive function, and visuospatial function and attention at posttest and 1-mo posttest. At posttest, YD maintained mobility and improved on dynamic balance. At 1-mo posttest, most mobility measures had improved relative to baseline. However, YD showed executive function and overall motor decline 6 mos after intervention. Adapted tango may have temporarily slowed disease progression and improved or maintained mobility and cognition. Gains were poorly maintained after 6 mos. Further study is warranted. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.