The aim of the study was to investigate the effects of a 6-mo exercise program on cognition and mobility in participants with multiple sclerosis.
This is a prospective, single-blind, controlled clinical trial.
A community rehabilitation program within a large metropolitan health service.
Twenty-eight patients with multiple sclerosis were referred for outpatient rehabilitation.
Participants were allocated to one of two groups and undertook a cognitive-motor exercise program or monitoring (control group).
Cognition and mobility were the main outcome measures. Cognition was evaluated using the Mini-Mental State Examination and the Frontal Assessment Battery. Mobility was assessed with the Timed Get Up and Go test, applied with and without dual task distractors.
The findings showed benefits provided by exercise on cognition and mobility. Differently, participants of the control group did not have significant changes in cognition scores after 6 mos of follow-up and had a worse performance in mobility tests.
Six months of exercise provided benefits to cognition and mobility in adults with multiple sclerosis. This trial was registered prospectively with the Brazilian Clinical Trials Register, ID: RBR-9gh4km (http://www.ensaiosclinicos.gov.br/rg/?q=RBR-9gh4km).
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Upon completion of this article, the reader should be able to: (1) Recognize the physical and cognitive decline in multiple sclerosis; (2) Identify the importance of exercise on cognition and mobility in patients with multiple sclerosis; and (3) Appreciate the potential benefit of dual tasking in the rehabilitation of individuals with multiple sclerosis.
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From the Faculty of Medicine, Universidade Federal University de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil (LAF, GC); Multiple Sclerosis Outpatient Clinic, Hospital Complex, Campo Grande, Brazil (PRS); Institute of Health, Universidade Federal University de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil (DSS, GC); and Department of Physiotherapy at the Universidade Estadual de Londrina, Londrina, Brazil (SMS).
All correspondence should be addressed to: Gustavo Christofoletti, PhD, Institute of Health, Universidade Federal de Mato Grosso do Sul, Av. Universitária, s/n, Caixa Postal 549, Campo Grande, MS, Brazil.
Clinical Trial Identifier: RBR-9gh4km (http://www.ensaiosclinicos.gov.br/rg/?q=RBR-9gh4km).
Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.
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