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Levodopa/Carbidopa to Improve Motor Function Subsequent to Brain Tumor Excision

Ennis, Jesse D. MD; Harvey, David MD, FRCPC; Ho, Enoch MPH, RPT; Chari, Vinjamuri MD, FRCPC; Graham, Andrew PhD; Nesathurai, Shanker MD, MPH, FRCPC

American Journal of Physical Medicine & Rehabilitation: April 2013 - Volume 92 - Issue 4 - p 307–311
doi: 10.1097/PHM.0b013e318278dc20
Original Research Articles
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Objective The aim of this study was to evaluate the role of levodopa/carbidopa as an augmenting agent to improve motor recovery after brain tumor excision.

Design This case report is structured as an n-of-1 style trial. The study patient was an outpatient with residual hemiparesis secondary to removal of benign oligoastrocytoma seen in an outpatient physiatry practice at an academic center. The study intervention was levodopa/carbidopa vs. placebo, combined with a structured 6-wk physiotherapy regimen. Outcomes were measured using the motor subscale of the Fugl-Meyer Assessment to assess for motor recovery.

Results The mean motor Fugl-Meyer Assessment score for the levodopa/carbidopa weeks was 6.90 points greater than the mean score for placebo. The results were significant at P < 0.05.

Conclusions Levodopa/carbidopa may have a beneficial effect on improving motor recovery after sustaining a brain injury as a result of tumor excision.

From the Physical Medicine and Rehabilitation Training Program, Department of Postgraduate Medicine, McMaster University, Hamilton, Canada (JE, DH, EH, VC, SN); Division of Physical Medicine and Rehabilitation, Department of Medicine, Hamilton Health Sciences, Hamilton, Canada (DH, VC, AG, SN); and Division of Physical Medicine and Rehabilitation, Department of Medicine, Saint Joseph’s Healthcare, Hamilton, Canada (SN).

All correspondence and requests for reprints should be addressed to: Jesse Ennis, MD, Regional Rehabilitation Centre, Hamilton Health Sciences, 300 Wellington St North, Hamilton, Ontario, Canada.

Submitted for consideration as a poster at the 2012 annual meetings of the Canadian Association of Physical Medicine & Rehabilitation and the American Academy of Physical Medicine and Rehabilitation.

Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.

© 2013 Lippincott Williams & Wilkins, Inc.