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The Relationship Between Health-Related Quality-of-Life and Disability in Patients with Controlled Epilepsy

A Cross-Sectional Observational Study

Quintas, Rui, MSc; Alvarez, Ana Sabela, MSc; Koutsogeorgou, Eleni, MA; Cerniauskaite, Milda, MSc; Meucci, Paolo, MA; Sattin, Davide, PsyD; Leonardi, Matilde, MD; Raggi, Alberto, PsyD

American Journal of Physical Medicine & Rehabilitation: February 2012 - Volume 91 - Issue 13 - p S31–S38
doi: 10.1097/PHM.0b013e31823d4db9
Original Research Articles

Objective The aims this study were to assess the impact of epilepsy on the health-related quality-of-life (HRQoL) of patients and on patterns of disability and to describe the relationship between disability and HRQoL in adult patients with controlled epilepsy.

Design Disability was measured with the World Health Organization Disability Assessment Schedule, second version (WHO-DAS II), whereas HRQoL was measured with the 36-item Short-Form Health Survey (SF-36). The relationships between SF-36 and WHO-DAS II were evaluated with Pearson correlation. The impact of epilepsy on disability and HRQoL was assessed by comparing WHO-DAS II and SF-36 scores with the Italian normative values and by evaluating different disability and HRQoL profiles in patients self-reporting change in health state against those reporting no change.

Results Few differences between patients’ and normative scores were observed. In particular, patients with a stable health state reported higher HRQoL and lower disability status, compared with those reporting an improvement or a decline in health state. The relationships between WHO-DAS II and SF-36 were significant but were generally low or moderate.

Conclusions Disability and HRQoL scores of patients with controlled epilepsy were not significantly different compared with those of the general population, in particular among stable patients. Measures of HRQoL and disability evaluate different psychosocial aspects of epilepsy and can be used jointly to evaluate outcomes.

From the Neurological Institute C Besta IRCCS Foundation, Neurology, Public Health, and Disability Unit, Milan, Italy.

All correspondence and requests for reprints should be addressed to: Matilde Leonardi, MD, Neurology, Public Health, and Disability Unit, Neurological Institute C Besta IRCCS Foundation, Via Celoria 11, Milan 20133, Italy.

Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article.

This study was conducted within the Multidisciplinary Research Network on Health and Disability in Europe project (European Commission project funded within the Sixth Framework Programme, MRTN-CT-2006-035794).

© 2012 Lippincott Williams & Wilkins, Inc.