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Pilocarpine for the Treatment of Refractory Dry Mouth (Xerostomia) Associated with Botulinum Toxin Type B

Dave, Shashank J. DO

American Journal of Physical Medicine & Rehabilitation: August 2008 - Volume 87 - Issue 8 - p 684-686
doi: 10.1097/PHM.0b013e31817fc287
Case Report: Spasticity

Dave SJ: Pilocarpine for the treatment of refractory dry mouth (xerostomia) associated with botulinum toxin type B. Am J Phys Med Rehabil 2008;87:684–686.

A woman with spastic hemiparesis from a stroke was injected with botulinum toxin type B (BoNTB) at a dose of 10,000 U. Although this had the desired effect of a reduction in her spasticity, she also developed severe dry mouth, which became refractory to local remedies such as moist towels, lip balms, and throat lozenges. She was then given pilocarpine (a muscarinic agonist) at a dose of 5 mg, three times a day, to which she responded well. This report describes another treatment option in rare cases of severe dry mouth after administration of BoNTB.

From the Department of Physical Medicine and Rehabilitation, Indiana University School of Medicine, Indianapolis, Indiana; and the Rehabilitation Hospital of Indiana, Indianapolis, Indiana.

All correspondence and requests for reprints should be addressed to Shashank J. Dave, DO, Indiana University, Department of Physical Medicine and Rehabilitation, 541 N. Clinical Drive, Suite 626, Indianapolis, Indiana, 46202.


© 2008 Lippincott Williams & Wilkins, Inc.