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Pharmacological, Surgical, and Neurovascular Interventions to Augment Acute Aphasia Recovery

Hillis, Argye E. MD, MA

American Journal of Physical Medicine & Rehabilitation: June 2007 - Volume 86 - Issue 6 - p 426-434
doi: 10.1097/PHM.0b013e31805ba094
Review & Analysis: Brain Injury

Hillis AE: Pharmacological, surgical, and neurovascular interventions to augment acute aphasia recovery. Am J Phys Med Rehabil 2007;86:426–434.

Aphasia recovery has often been attributed to a combination of “spontaneous recovery” and rehabilitation. However, a variety of new pharmacological, surgical, and interventional neuroradiology procedures have been developed that can complement rehabilitation in the first days to weeks after stroke by restoring blood flow to dysfunctional but salvageable brain tissue. This paper will review the medical and surgical interventions to improve regional cerebral blood flow that recently have been shown to (1) augment aphasia recovery by improving tissue function, and (2) prevent expansion of the stroke that would otherwise impede recovery. Success with such treatments facilitates aphasia rehabilitation by improving the baseline language performance that must be improved further with language therapy.

From the Department of Neurology and Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland.

The studies reported in this paper were supported by NIH (NIDCD), through RO1 DC05375.

All correspondence and requests for reprints should be addressed to Argye E. Hillis, MD, MA, Professor of Neurology, Johns Hopkins University School of Medicine, Johns Hopkins Hospital, Phipps 126, 600 N. Wolfe Street, Baltimore, MD 21287.

© 2007 Lippincott Williams & Wilkins, Inc.