Original Articles: Review & Analysis: MusculoskeletalPhysiological Basis of FatigueEvans, William J. PhD; Lambert, Charles P. PhDAuthor Information From the Nutrition, Metabolism, and Exercise Laboratory, University of Arkansas for Medical Sciences, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas. A draft of this article was originally presented January 9–10, 2006, in Bethesda, Maryland, during the Musculoskeletal Research Conference jointly sponsored by the National Center for Medical Rehabilitation Research, the National Institute on Aging, the National Institute on Arthritis and Musculoskeletal Diseases, the Social Security Administration, and the Interagency Committee on Disability Research. There is no apparent conflict of interest related to the context of participation of the authors of this article. All correspondence and requests for reprints should be addressed to William J. Evans, University of Arkansas for Medical Sciences, 4301 W. Markham, Slot 806, Little Rock, AR 72205. American Journal of Physical Medicine & Rehabilitation: January 2007 - Volume 86 - Issue 1 - p S29-S46 doi: 10.1097/PHM.0b013e31802ba53c Buy Metrics Abstract Evans WJ, Lambert CP: Physiological basis of fatigue. Am J Phys Med Rehabil 2007;86(Suppl):S29–S46. This work summarizes our knowledge of the physiological basis of fatigue and the effects of exercise and pharmacological interventions on fatigue. Fatigue may be defined as physical and/or mental weariness resulting from exertion, that is, an inability to continue exercise at the same intensity with a resultant deterioration in performance. The concept of deconditioning in patients is discussed as well as the implications for their rehabilitation and exercise. Because fatigue may result from a number of causes, including loss of muscle mass, deconditioning, nutritional deficiencies, oxygen delivery, and anemia, it should be treated comprehensively. Antifatigue therapy should be the standard of care for most chronic conditions associated with fatigue. © 2007 Lippincott Williams & Wilkins, Inc.