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Beneficial Effect of Donepezil on Sensorimotor Function After Stroke

Berthier, Marcelo L. MD; Pujol, Jesús MD; Gironell, Alexandre MD; Kulisevsky, Jaime MD; Deus, Joan PhD; Hinojosa, Julían PhD; Soriano-Mas, Carles PhD

American Journal of Physical Medicine & Rehabilitation: September 2003 - Volume 82 - Issue 9 - p 725-729
doi: 10.1097/01.PHM.0000083668.48396.84
Case Report: Stroke

Berthier ML, Pujol J, Gironell A, Kulisevsky J, Deus J, Hinojosa J, Soriano-Mas C: Beneficial effect of donepezil on sensorimotor function after stroke. Am J Phys Med Rehabil 2003;82:725–729.

Pharmacotherapy of poststroke sensorimotor deficits is currently used alone or combined with physiotherapy to promote recovery of mobility problems. This case study examined the effectiveness of donepezil hydrochloride (HCl) administered to a stroke patient with chronic, dense, left sensorimotor deficit. The patient received donepezil HCl (5 mg daily for 4 wk, followed by 10 mg daily for 12 wk) but no physiotherapy. Baseline and posttreatment evaluations were performed with the Fugl-Meyer scale and the Rivermead Mobility Index. One month after starting donepezil HCl (10 mg/day), sensorimotor function improved dramatically in the hemiplegic lower limb and shoulder. It was concluded that donepezil HCl may be an effective treatment for improving sensorimotor function in chronic stroke patients. Randomized controlled trials are required to support these preliminary findings.

From the Department of Medicine, University of Malaga School of Medicine, Malaga, Spain (MLB); the Magnetic Resonance Center of Pedralbes, CETIR, Barcelona, Spain (JP, JD, CSM); the Movement Disorder Section, Department of Neurology, Sant Pau Hospital and Autonomous University of Barcelona, Barcelona, Spain (AG, JK); and the Marine Hospital of Torremolinos, Malaga, Spain (JH).

Address requests for reprints to Marcelo L. Berthier, MD, Departamento de Medicina Facultad de Medicina, Universidad de Málaga, Campus Universitario Teatinos, 29.071, Málaga, España.

© 2003 Lippincott Williams & Wilkins, Inc.