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Functional MRI Evidence for Motor Cortex Reorganization Adjacent to a Lesion in a Primary Motor Cortex

Jang, Sung Ho MD; Han, Bong Soo PhD; Chang, Yongmin PhD; Byun, Woo Mok MD; Lee, Jun MD; Ahn, Sang Ho MD

American Journal of Physical Medicine & Rehabilitation: November 2002 - Volume 81 - Issue 11 - p 844-847
Research Article: Brain Injury

Jang SH, Han BS, Chang Y, Byun WM, Lee J, Ahn SH: Functional MRI evidence for motor cortex reorganization adjacent to a lesion in a primary motor cortex. Am J Phys Med Rehabil 2002;81:844–847.

Objective The object of this study was to verify motor cortex reorganization in patients with primary motor cortex injury using functional magnetic resonance imaging.

Design Ten control subjects and two patients with primary motor cortex injury, caused by a traumatic brain injury in patient 1 and meningioma in patient 2, were evaluated. Functional magnetic resonance imaging was performed using the blood oxygenation level–dependent technique at 1.5 T with hand movements.

Results The contralateral primary sensorimotor cortex was activated by unaffected hand movements. However, only the contralateral primary sensory cortex in patient 1 and the premotor area in patient 2 were activated by affected hand movements, which were totally absent in control subjects.

Conclusion We believe that the hand motor function of injured primary motor cortex was shifted into the primary sensory cortex in patient 1 and premotor area in patient 2. In conclusion, this finding may reflect a functional reorganization of the motor area in patients with a primary motor cortex injury.

From the Departments of Physical Medicine and Rehabilitation (SHJ, SHA), Diagnostic Radiology (WMB), and Neurology (JL), Yeungnam University School of Medicine, Taegu, South Korea; and the Department of Radiology (BSH, YC), Kyungpook National University School of Medicine, Taegu, South Korea.

Supported by a grant from the Yeungnam University Medical Center (2000); Bong Soo Han was supported by a postdoctoral grant from Kyungpook National University.

All correspondence and requests for reprints should be addressed to Sung Ho Jang, MD, Department of Physical Medicine and Rehabilitation, School of Medicine, Yeungnam University, 317-1, Daemyungdong, Namku, Taegu 705-717, South Korea.

© 2002 Lippincott Williams & Wilkins, Inc.