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Serum 2-Microglobulin">β2-Microglobulin Reflects Increased Bone Resorption in Immobilized Stroke Patients

Sato, Yoshihiro, MD; Kuno, Haruko, MD; Kaji, Masahide, MD; Tsuru, Toshiomi, MD; Saruwatari, Naoko, MD; Oizumi, Kotaro, MD

American Journal of Physical Medicine & Rehabilitation: January 2001 - Volume 80 - Issue 1 - p 19-24
Research Article: Hemiplegia
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Sato Y, Kuno H, Kaji M, Tsuru T, Saruwatari N, Oizumi K: Serum 2-microglobulin">β2-microglobulin reflects increased bone resorption in immobilized stroke patients. Am J Phys Med Rehabil 2001;80:19–24.

Objective The so-called bone-derived growth factor, 2-microglobulin">β2-microglobulin, has a regulatory function in bone metabolism by stimulating osteoclast activity. We undertook this study because osteoclast activity is known to be enhanced in patients with immobilized stroke, suggesting that their 2-microglobulin">β2-microglobulin concentrations may be increased.

Design We studied 79 patients with acute stroke hemiplegia, including 36 men and 43 postmenopausal women ranging in age between 51 and 70 yr.

Results The mean Barthel Index was 43 and 42 for men and women, respectively. The serum 2-microglobulin">β2-microglobulin concentration was increased in male and female patients, compared with the findings of 44 age-matched control subjects, and the serum concentration of pyridinoline cross-linked carboxyterminal telopeptide of type 1 collagen was also increased in male and female patients, compared with the findings of the control subjects. Serum concentrations of pyridinoline cross-linked carboxyterminal telopeptide of type 1 collagen correlated negatively with Barthel Index scores in both genders, indicating increased bone resorption caused by immobilization in these patients. Linear regression analysis revealed a positive correlation between 2-microglobulin">β2-microglobulin and pyridinoline cross-linked carboxyterminal telopeptide of type 1 collagen in both genders.

Conclusions These findings suggest that 2-microglobulin">β2-microglobulin reflects osteoclastic activity in response to stroke-induced immobilization in both genders. 2-microglobulin">β2-microglobulin is a useful indicator of bone resorption in patients with immobilized stroke.

From the Department of Neurology (YS, HK, MK) and the First Department of Internal Medicine (TT, NS, KO), Kurume University Medical Center, Kurume, Japan.

All correspondence and requests for reprints should be addressed to Yoshihiro Sato, MD, Department of Rehabilitation Medicine, Institute of Neurological Diseases, Hirosaki University, 5 Zaifu-cho, Hirosaki 036-8562, Japan.

© 2001 Lippincott Williams & Wilkins, Inc.