Feature ArticlesCE: Multisystem Inflammatory Syndrome in Children A ReviewShields, Kerry MSN, CPNP-AC; Atlas, Kristin MSN, CPNP-AC, ACCNS-P; Farber, Jessica Strohm DNP, CPNP-AC; Lebet, Ruth PhD, RN, PCNS-BC Author Information Kerry Shields, Kristin Atlas, and Jessica Strohm Farber are pediatric critical care NPs at the Children's Hospital of Philadelphia (CHOP). Ruth Lebet is a nurse scientist at CHOP's Center for Pediatric Nursing Research and Evidence-Based Practice. Contact author: Kerry Shields, [email protected]. The authors and planners have disclosed no potential conflicts of interest, financial or otherwise. A podcast with the authors is available at www.ajnonline.com. AJN, American Journal of Nursing 121(5):p 26-37, May 2021. | DOI: 10.1097/01.NAJ.0000749756.12090.63 Buy CE Test Metrics AbstractIn Brief The coronavirus disease 2019 (COVID-19) pandemic has impacted the health of children worldwide. Although overall mortality from COVID-19 in children remains low, an associated multisystem inflammatory disorder has emerged. The disorder has been recognized and named multisystem inflammatory syndrome in children (MIS-C) by the World Health Organization and the Centers for Disease Control and Prevention. This comprehensive review describes the epidemiology, pathophysiology, signs and symptoms, other potential diagnoses, and treatments relevant to MIS-C. The review also includes patient and family education and anticipatory guidance, and discusses nursing implications for nurses working in various roles and settings, including direct care, research, and public health. This comprehensive evidence-based review describes the epidemiology, pathophysiology, signs and symptoms, alternative potential diagnoses, and treatment options of MIS-C, an emerging pediatric disorder associated with COVID-19. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.