Journal WatchMelatonin Safe And Effective for the Prevention of Migraine HeadacheRosenberg, KarenAJN, American Journal of Nursing: September 2016 - Volume 116 - Issue 9 - p 69 doi: 10.1097/01.NAJ.0000494704.01488.c1 Buy Metrics Abstract According to this study: Melatonin at a dosage of 3 mg/day is more effective than placebo in the prevention of migraine. Melatonin may be an option for patients who are sensitive to other drugs used to prevent migraine or who prefer to use natural products. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.