Limits on the Use of an Antifungal DrugAschenbrenner, Diane S. MS, RNAJN The American Journal of Nursing: November 2013 - Volume 113 - Issue 11 - p 22,23 doi: 10.1097/01.NAJ.0000437106.68608.46 Drug Watch Abstract Author Information Serious hepatic injury, including liver failure or death, is possible with use of the antifungal ketoconazole (Nizoral). Use of oral ketoconazole is now limited to the treatment of serious fungal disorders that haven't responded to other antifungal drugs or cases in which a patient cannot tolerate other antifungals. Diane S. Aschenbrenner recently retired as course coordinator for undergraduate pharmacology at Johns Hopkins University School of Nursing in Baltimore, MD. She also coordinates Drug Watch: email@example.com. © 2013 Lippincott Williams & Wilkins. All rights reserved.