Treatment for Graves' Disease Poses Risk of Liver FailureAschenbrenner, Diane S. MS, APRN, BCAJN, American Journal of Nursing: October 2009 - Volume 109 - Issue 10 - p 33 doi: 10.1097/01.NAJ.0000361486.99352.f9 Drug Watch Abstract Author InformationAuthors Article MetricsMetrics Propylthiouracil, used in the treatment of Graves' disease, can increase the risk of serious liver injury, including liver failure and death. The FDA recommends limiting the use of propylthiouracil to patients who are allergic to or intolerant of methimazole and to women in the first trimester of pregnancy. All patients taking propylthiouracil should be monitored for signs of liver injury. Diane S. Aschenbrenner is the course coordinator for undergraduate pharmacology at Johns Hopkins University School of Nursing in Baltimore, MD. She also coordinates Drug Watch: firstname.lastname@example.org. © 2009 Lippincott Williams & Wilkins, Inc.