Continuing Medical Education Questions: July 2014 DeVault, Kenneth R MD, FACG; Al Bashir, Siwar MD; Narula, Neeraj MD; Rosenberg, Morgan MD; Voglis, Stefanos MD
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Article Title: ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury
doi: 10.1038/ajg.2014.176
Questions:
In which one of the following scenarios would liver biopsy be considered inappropriate in suspected drug-induced liver injury (DILI)?
A. If autoimmune hepatitis remains a competing etiology and immunosuppressive therapy is contemplated.
B. If continued use or re-exposure to the suspected offending agent is expected.
C. If there is a unrelenting rise in liver biochemistries or signs of worsening liver function despite stopping the suspected offending agent.
D. If the peak alanine transaminase (ALT) level has not fallen by more than 50% at 30–60 days.
Which one of the following drugs can present with a DILI reaction similar to autoimmune hepatitis?
A. Amiodarone
B. Methotrexate
C. Amoxicillin
D. Anti-TNF agents
E. Macrolides
Which one of the following drugs implicated in DILI may lead to a pattern of cholestasis?
A. Valproate
B. Minocycline
C. Anabolic steroids
D. Green tea extract
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