EDITORIALSThe Unfulfilled Promise of Prokinetics for Functional Dyspepsia/Postprandial Distress SyndromeTack, Jan MD, PhD1; Van den Houte, Karen MPharm1; Carbone, Florencia PhD1 Author Information 1Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, Leuven, Belgium. Correspondence: Jan Tack, MD, PhD. E-mail: [email protected]. The American Journal of Gastroenterology 114(2):p 204-206, February 2019. | DOI: 10.14309/ajg.0000000000000072 Buy Metrics Abstract Functional dyspepsia (FD) is subdivided into epigastric pain syndrome and postprandial distress syndrome according to the Rome IV consensus. Based on the assumption that disordered gastric motility is a key pathophysiologic factor in postprandial distress syndrome, prokinetic agents are often proposed as the treatment of choice for this subgroup. Although a meta-analysis suggests that prokinetic agents may be efficacious and safe in FD, there is a lack of widely available agents of proven efficacy. This review analyzes some of the difficulties and challenges in establishing therapeutic efficacy of prokinetic drugs in FD. © 2019 by The American College of Gastroenterology
