Secondary Logo

Journal Logo


Updates on Age to Start and Stop Colorectal Cancer Screening: Recommendations From the U.S. Multi-Society Task Force on Colorectal Cancer

Patel, Swati G. MD, MS1,2; May, Folasade P. MD, PhD, MPhil3,4; Anderson, Joseph C. MD5,6; Burke, Carol A. MD7; Dominitz, Jason A. MD, MHS8; Gross, Seth A. MD9; Jacobson, Brian C. MD, MPH10; Shaukat, Aasma MD, MPH11; Robertson, Douglas J. MD, MPH5

Author Information
The American Journal of Gastroenterology: January 2022 - Volume 117 - Issue 1 - p 57-69
doi: 10.14309/ajg.0000000000001548
  • Free
  • CME Test
  • CME


The U.S. Multi-Society Task Force on Colorectal Cancer (MSTF), comprised of representatives from the American College of Gastroenterology, the American Gastroenterological Association, and the American Society for Gastrointestinal Endoscopy, has long supported colorectal cancer (CRC) screening in the general population.1 The MSTF recommendations on screening of average-risk individuals, defined as those without a personal or family history of colorectal neoplasia (CRC or neoplastic colorectal polyps) and those without clinical features of CRC (eg, gastrointestinal bleeding, iron deficiency anemia, or abnormal imaging) were last updated in 2017.2 At that time, the MSTF presented recommendations offering average-risk individuals a tiered approach to CRC screening in which tier 1 tests were colonoscopy and fecal immunochemical test (FIT) beginning at age 45 for Black Americans (African Americans) and age 50 for non-Black Americans. The 2017 recommendations also emphasized that the target for CRC screening should be early detection of CRC (ie, curable) and early detection and removal of high-risk precancerous lesions—with the goal of decreasing both CRC-associated mortality and CRC incidence. The consensus statement recommended screening until at least age 75 or when life expectancy is less than 10 years, that screening should involve shared decision-making between ages 76 and 85, and that individuals beyond age 85 should not undergo screening.

This Consensus Statement provides updated recommendations on average-risk screening, focused on when to start and when to stop CRC screening. A detailed review of approaches to screening, specific screening tests, screening targets, and quality of screening are reviewed in our prior screening recommendations.2 Similarly, recommendations for colorectal neoplasia surveillance are reviewed in MSTF surveillance guidelines.3,4


Literature review

A focused literature search was performed by medical librarian consultants to address the principal questions of when to begin and when to stop colorectal screening in average-risk individuals, with the intended targets of screening as early detection of colorectal adenocarcinoma and high-risk precancerous lesions. Our search also aimed to address a secondary question of preferred screening modality.

For when to start screening, Ovid Medline, Embase, and Web of Science were queried in February 2021. This search was limited to human participants, with no limitations on language, country of publication, or publication date. This resulted in 10,123 unique citations; 9,791 were excluded based on title and abstract review, and 332 full text articles were reviewed.

The literature search for when to stop average-risk screening was conducted in March 2021 and queried the same databases. This search was limited to publications from 2017 to 2021 and identified 109 citations from which 37 full-text articles were reviewed. For both questions, a search in the Cochrane Database of Systematic Reviews (2014 to March 5, 2021) and the Database of Abstracts of Reviews and Effects (2014 to March 5, 2021) was updated from the 2017 recommendations.

Systematic reviews, meta-analyses, gastroenterology textbooks, and editorials were searched manually for additional pertinent references. Relevant publications were identified by searching a combination of keywords and database-specific indexing terms for the CRC screening with the following subheadings: fecal occult blood test, a FIT, colonoscopy, sigmoidoscopy, computerized tomography and CT colonoscopy, fecal-DNA, serum testing, and cost-effectiveness. Case reports and studies performed in individuals with inflammatory bowel disease, family history of colorectal neoplasia, prior CRC or polyps, or hereditary CRC syndromes were excluded. All results were exported and de-duplicated in EndNote (Clarivate Analytics, Philadelphia, PA, USA).

Process and levels of evidence

Evidence-based weighted recommendations are provided with supporting discussion to help guide clinicians. The MSTF develops consensus guidance statements through evidence review to develop draft statements that are moved to consensus through a series of joint teleconferences. The completed document was then submitted for review and approval by the governing boards of the American College of Gastroenterology, American Gastroenterological Association, and American Society for Gastrointestinal Endoscopy.

The use of Grading of Recommendations Assessment, Development and Evaluation (GRADE) has been outlined in prior MSTF documents.4 The GRADE process separates evaluation of the quality of the evidence to support a recommendation from the strength of that recommendation. This is done in recognition of the fact that although the quality of the evidence impacts the strength of the recommendation, other factors can influence a recommendation, such as side effects, individual preferences, values, and cost. The MSTF has adapted the GRADE approach by performing critical review of evidence without traditional meta-analysis. Similar to prior statements, “strong recommendations” are those that would be chosen by most well-informed individuals. “Weak recommendations” are those where individuals’ values and preferences may play a larger role than the quality of evidence available. Strong recommendations presented in this article are preceded by “we recommend,” whereas weak recommendations are presented as “we suggest.”


Over the last several decades, CRC incidence and mortality rates have decreased in the United States.5 Reasons for this decline include increasing uptake of CRC screening and colonoscopic polypectomy in those over age 50 and changing risk factors (eg, decreased smoking, increased aspirin use).6,7 Recent data, however, show that CRC incidence rates in individuals ages 50 to 64 have increased by 1% annually between 2011 and 2016.5,8 Similarly, CRC incidence and mortality rates in persons under age 50, termed early-age onset CRC (EAO-CRC), are also increasing (Figure 1).9 Detailed reviews of EAO-CRC epidemiology, clinicopathologic features, pathogenesis, and risk factors are presented elsewhere.10-12 The discussion below is focused on data that inform screening considerations.

Figure 1.
Figure 1.:
Age-adjusted Surveillance, Epidemiology, and End Results (SEER) incidence rate trends from 1975 to 2018 of colorectal, colon-only site, and rectal-only site adenocarcinoma by age. Incidence rates acquired by E.M., J.K., and M.Z. from SEER 9 Registry (see acknowledgments) using the same methodology as performed in Montminy et al.15

Epidemiology of EAO-CRC

Overall incidence and mortality.

In the United States, CRC is the second most common cancer and the third leading cause of cancer-related death in men and women under age 50.13 In 2020, 11% of all colon cancer and 15% of all rectal cancer diagnoses were estimated to occur in individuals under age 50.5 CRC incidence has been steadily increasing in younger Americans for the last several decades, with the sharpest rise seen in the incidence of rectal cancer (Figure 1). Based on data from the North American Association of Central Cancer Registries, which includes 47 states and the District of Columbia, there has been a 1.1% increase per year (95% confidence interval [CI], .3%-2.0%) from 2006 to 2015 for those under age 50.14 This includes an increase of .7% per year (95% CI, .5%-.9%) for colon tumors and 1.7% per year (95% CI, 1.4%-2.0%) for rectal tumors.14 When stratified by tumor histology and age from Surveillance, Epidemiology, and End Result 18 (SEER 18) spanning 2000 to 2016, for those 20 to 29, 30 to 39, and 40 to 49, there was a 5.6% (95% CI, .5%-11.1%), 1.6% (95% CI, 1.2%-2.0%), and .9% (95% CI, .7%-1.2%) annual percentage increase in overall colorectal adenocarcinomas and 1.6% (95% CI, .1%-3.1%), 2.2% (95% CI, 1.7%-2.7%), and 1.2% (95% CI, .7%-1.7%) increase in rectal adenocarcinomas, respectively.15 Although the steepest increase in adenocarcinoma incidence rates was found in 20- to 29- and 30- to 39-year-olds, a 13% increase in colon adenocarcinoma and 16% increase in rectal adenocarcinoma rates were found in those aged 40 to 49 years from 2000 to 2016.15

The current CRC incidence rates in individuals ages 45 to 49 are similar to the incidence rates observed in 50-year-olds in 1992, before widespread CRC screening was performed. From the 2001 to 2010 in the SEER Registry, the CRC incidence among 45- to 49-year-olds was 30.8 and 25.9 per 100,000 for men and women, respectively.13 CRC incidence in persons aged 50 years in 1992 was 25.6 per 100,000.16,17 Using historical (1975-2010) population-based SEER data, researchers forecast that for individuals ages 35 to 49, colon and rectal cancer incidence rates will increase by 27.7% and 46.0%, respectively, by 2030.18

Based on data from the National Center for Health Statistics,19 in 45- to 49-year-olds, mortality from malignant neoplasms of the colon has increased from 6.4 per 100,000 in 1999 to 6.6 per 100,000 in 2019. Mortality from malignant neoplasms of the rectum in this population has increased from 1.3 per 100,000 in 1999 to 1.7 per 100,000 in 2019. Over this same period of time, colon cancer mortality rates have decreased in 50- to 59-year-olds (15.4 to 12.5/100,000), 60- to 69-year-olds (44.1 to 23.9/100,000), and 70- to 79-year-olds (92.7 to 36.1/100,000). Similarly, rectal cancer mortality rates have also decreased in 60- to 69-year-olds (6.5 to 5.1/100,000) and 70- to 79-year-olds (11.9 to 7.5/100,000), although rectal cancer rates have increased in 50- to 59-year-olds (2.6 to 3.1/100,000). This increased mortality from rectal cancer in 50- to 59-year-olds may reflect the cohort effect discussed below.

Birth cohort effect.

Siegel et al9 used age-period-cohort modeling to determine the influence of period effects (ie, because of changes in clinical practice) versus birth cohort effects (ie, because of changes in generation-specific risk factors) in the rising incidence of EAO-CRC. SEER incidence data from 1974 to 2013 were analyzed by age group. Interestingly, the incidence curve for those ages 50 to 54 is similar to the older age groups in the 1970s to 1980s but then reflects the younger age group after the mid-1990s. Siegel et al concluded that the younger birth cohorts are carrying the elevated risk with them as they age and that this risk supports a strong cohort effect in the data. The inflection point for the birth cohort effect is for individuals born after 1960. This strong birth cohort effect suggests that exposures increasingly prevalent in early life, or accumulated across the life course, may contribute to the increasing incidence of EAO-CRC.

Racial and ethnic differences in EAO-CRC.

Between 2000 and 2013, EAO-CRC incidence increased 2.5% in Native American/Alaskan natives, 2.3% in non-Hispanic Whites, 1.0% in non-Hispanic blacks, and .2% in Asian/Pacific Islanders.8 In an analysis of SEER data, Murphy et al20 reported that from 1992 to 1996 to 2010 to 2014, CRC incidence increased from 7.5 to 11.0 per 100,000 in White individuals and from 11.7 to 12.7 per 100,000 in black individuals. The increase in rectal cancer was larger in White (from 2.7 to 4.5 per 100,000) compared with Black (from 3.4 to 4.0 per 100,000) individuals.20

The recent increase in mortality rates is limited to White individuals, among whom there has been a 1.4% increase per year from 2004 to 2014 (3.6/100,000 to 4.1/100,000). Among Black individuals, mortality rates declined by .4% to 1.1% annually21; however, Black individuals still had a higher overall risk of cancer-related death (colon cancer: hazard ratio, 1.36; 95% CI, 1.27-1.45; rectal cancer: hazard ratio, 1.52; 95% CI, 1.38-1.68) from 2000 to 2009 when compared with White individuals.22 Five-year relative survival was 54.9% in Black individuals compared with 68.1% in White individuals.22

Clinical and pathologic features

Most CRCs in young patients are identified because of signs and symptoms rather than incidentally or through screening (Table 1). In a series including more than 1,000 patients with EAO-CRCs, the most common presenting symptom was rectal bleeding (50.8%), followed by abdominal pain (32.5%) and change in bowel habits (18.0%).23 When compared with later-age onset CRC (LAO-CRC) patients, Chen et al24 reported that EAO-CRC patients were more likely to present with symptoms of hematochezia (28.8% vs 23.2%, P < .01) and abdominal pain (41.2% vs 27.2%, P < .01). EAO-CRC patients experienced symptoms for longer periods before diagnosis (243 vs 154 days) and had a longer delay to diagnosis (152 vs 87 days) compared with LAO-CRC patients (Table 1).24

Table 1.
Table 1.:
Clinical and pathologic features of CRC diagnosed in patient under and over age 50

LAO-CRC patients are more likely to have right-sided cancers (31.1% vs 20.0%, P < .001), and EAO-CRC patients are more likely to have rectal cancer (31.2% vs 22.4%, P < .001) (Table 1).25 EAO-CRC also appears to have more aggressive histopathology than LAO-CRC. Overall, mucinous and signet ring histologies were seen in 10.0% to 14.5%26-29 and 2.0% to 13.0%26,27,29 of EAO-CRCs, respectively, with up to 27.9% of cancers being poorly differentiated or undifferentiated.24 Data from the National Cancer Database showed that EAO-CRC was modestly, but significantly, more likely to have a mucinous and/or signet-ring histology compared with LAO-CRCs (12.6% vs 10.8%, P < .01) and poor or no differentiation (20.4% vs 18%, P < .01).30

EAO-CRC is diagnosed at a more advanced stage at the time of detection than LAO-CRC (Table 1). Abdelsattar et al25 reported a relative risk of 1.37 (95% CI, 1.33-1.41) and 1.58 (95% CI, 1.53-1.63) for younger patients to present with regional or distant metastasis, respectively, compared with older patients. Chen et al24 found that the difference in stage at presentation between EAO-CRC and LAO-CRCs could not be explained simply by a longer time between the onset of symptoms and diagnosis because younger patients with stage III or IV disease had shorter symptom and workup periods compared with those with stage I or II disease. Thus, advanced stage at diagnosis is not likely explained by longer dwell time or time to diagnosis.

Despite seemingly later-stage and more-aggressive histology at presentation, EAO-CRC patients appear to have equivalent, if not improved, survival. In one large report of SEER data, the stage-adjusted, cancer-specific survival was better in younger patients compared with those diagnosed over age 50 (local: 95.1% vs 91.9%, P < .001; regional: 76% vs 70.3%, P < .001; distant: 21.3% vs 14.1%, P < .001).25

It is important to note that the literature on EAO-CRC clinical and pathologic features is drawn from retrospective series that have not consistently separated sporadic cancers from those occurring in patients with hereditary cancer syndromes. Two studies characterized the prevalence of germline pathogenic variants in cohorts of EAO-CRC patients with multigene panel testing. Although these were small cohorts, they suggest that left-sided cancers are more common in sporadic EAO-CRC compared hereditary EAO-CRC. Pearlman et al31 reported pathogenic variants in 16% of 450 unselected CRC cases. Left-sided cancers (including rectal) comprised a larger proportion of sporadic EAO-CRCs (74.9%) compared with those with a germline pathogenic variants (58.3%) in 1 of 25 cancer susceptibility genes (which comprised mismatch repair genes and other genes associated with CRC and noncolorectal cancer risk). Similarly, Stoffel et al32 reported pathogenic variants in 18% of 315 EAO-CRC patients who underwent clinical genetic testing and found that 72.6% of sporadic EAO-CRCs were left-sided versus 38.0% EAO-CRCs in patients with germline pathogenic variants.

Somatic alterations and molecular characteristics of EAO-CRC

The somatic alterations and molecular characteristics of CRCs diagnosed in patients ages 45 to 49 years are similar to CRCs diagnosed in patients age ≥50. In a 2019 a multicenter study, 18,218 CRC cases were subjected to targeted next-generation genomic sequencing of 3,769 exons from 403 cancer-related genes and of 47 introns commonly rearranged in cancer tissues.33 The patient groups were divided into ages <40 years (n = 1,420), 40 to 49 years (n = 3,248), and >50 years (n = 13,550).33 Although tumors of patients <40 years of age showed significant differences when compared with tumors in those ages >50, there did not appear to be a significant difference in somatic alterations when comparing tumors from 40 to 49-year-olds compared with >50-year-olds.

Guinney et al34 described 4 consensus molecular subtypes (CMSs) of CRC: CMS1 (microsatellite instability immune), hypermutated, microsatellite unstable, and strong immune activation; CMS2 (canonical), epithelial, marked WNT and MYC signaling activation; CMS3 (metabolic), epithelial and evident metabolic dysregulation; and CMS4 (mesenchymal), prominent transforming growth factor–β activation, stromal invasion, and angiogenesis. Willauer et al35 described the molecular features of 36,000 CRCs and demonstrated that CRCs diagnosed in patients under age 50 are not a homogenous group. Patients younger than 40 were predominantly CMS1 or CMS2, whereas patients over age 40 were more likely CMS3 and CMS4. The molecular similarities in patients over age 40 may indicate a birth cohort effect as described above. The similar biology of tumors in 40- to 49-year-olds compared with tumors in those over age 50 suggest they may similarly be appropriate targets for screening.


Colonoscopy screening

Data are limited on the yield of CRC screening among average-risk individuals <50 years in the United States. Abualkhair et al36 reported a sharp increase in CRC incidence rates in 50-year-olds compared with 49-year-olds, likely because of screen-detected asymptomatic cancers that were likely present in 45- to 49-year-olds.

A few studies have assessed the yield of CRC screening in average-risk individuals under age 50 in the United States (Table 2). In 2002, Imperiale et al37 presented results from 906 average-risk adults ages 40 to 49 (61% men) who underwent colonoscopy between 1995 and 2000 as part of an employer-based screening program. They found that 8.7% of their cohort had a nonadvanced adenoma and 3.5% had advanced adenomas. Rundle et al38 included 553 average-risk individuals ages 40 to 49 who underwent colonoscopy between 2004 and 2006 as part of an employer-sponsored wellness examination and reported nonadvanced adenomas in 12.3% and advanced adenomas in 2% of their cohort. Friedenberg et al39 reported yield of average-risk screening colonoscopy in 304 black Americans ages 45 to 49 and found nonadvanced adenomas in 12.2% and advanced adenomas in 8.9%. Lieberman et al40 reported a 4.3% rate of polyps >9 mm in 10,700 individuals younger than age 50 who underwent average-risk colonoscopy screening from 2000 to 2011. Eberth et al41 found nonadvanced adenomas in 19.1% of Black Americans ages 45 to 49 years undergoing average-risk screening colonoscopy. For each study, advanced adenomas were defined as adenomas ≥1 cm, with villous architecture or with high-grade dysplasia.

Table 2.
Table 2.:
Summary of studies reporting yield of colonoscopy screening in average-risk individuals under age 50

There are several limitations to these studies. First, the earlier studies may not reflect the current prevalence of colorectal neoplasia. Second, the generalizability of these studies to the broader U.S. population are limited in that 2 studies included Black Americans only and 2 were part of employer-based programs, disproportionately represented by White individuals and those of higher socioeconomic status. Although the sample size was large for the Lieberman et al40 study, data on nonadvanced adenomas and CRC were not available, and the retrospective design raises concern that individuals under age 50 undergoing colonoscopy may not have been average risk. The other studies had small sample sizes and no reported CRCs. The studies in non-Black American populations did not stratify results further by age group (40-44 vs 45-49). Finally, these studies were cross-sectional or retrospective in design and thus do not provide data on the efficacy of colonoscopy in decreasing metachronous CRC/advanced colorectal neoplasia incidence or CRC-related mortality.

Multiple international studies have described the yield of colonoscopy in average-risk individuals under age 50 (Table 2). Studies with available data for individuals ages 45 to 49 reported nonadvanced adenoma rates ranging from 8.2% to 20.2% and advanced adenoma rates of 1.2% to 12.5%.42-45 Kolb et al46 conducted a systematic review and meta-analysis of screening colonoscopy performed in 51,811 average-risk individuals under age 50 from 17 international studies published from 2002 to 2020, 5 of which were performed in the United States. Among those ages 45 to 49, this systematic review and meta-analysis reported a pooled rate of any colorectal neoplasia of 17.8% (95% CI, 14.5-21.6) and advanced colorectal neoplasia of 3.6% (95% CI, 1.9-6.7). Based on these pooled rates, 28 average-risk individuals ages 45 to 49 need to undergo screening colonoscopy to detect (and remove) 1 advanced polyp.46

Butterly et al47 recently reported rates of neoplasia in 45- to 49-year-olds using data from the New Hampshire Colonoscopy Registry. Because many adults younger than 50 years have colonoscopies for diagnostic indications as opposed to screening, they excluded symptoms shown to be associated with a high risk for advanced neoplasia, such as rectal bleeding, to better approximate an average-risk screening population. They combined colonoscopy findings in those who underwent colonoscopy for “low-risk” symptoms, such as abdominal pain and constipation, with those who had a screening indication. The low-risk symptoms had no association with advanced neoplasia (odds ratio, 1.00; 95% CI, .81-1.24), suggesting that patients with these symptoms likely represent an average-risk population. In the 45- to 49-year-old average-risk screening equivalent group, 17.5% had any colorectal neoplasia and 3.7% had advanced colorectal neoplasia.47 This study also found that 5.9% of the New Hampshire Colonoscopy Registry patients ages 45 to 49 had a clinically significant serrated polyp (defined as a sessile serrated polyp/lesion, a traditional serrated adenoma, a hyperplastic polyp ≥1 cm, or a hyperplastic polyp ≥5 mm proximal to the rectosigmoid), which was similar to those ages 50 to 54 years (6.1%).

Despite the limitations noted, these studies show that clinically significant neoplasia rates in 45- to 49-year-olds approaches the rates observed in 50- to 59-year-olds. Kolb et al46 compared neoplasia rates in 45- to 49-year-olds with rates observed in 50- to 59-year-olds within the same studies. The rate of advanced colorectal neoplasia in 45- to 49-year-olds and 50- to 59-year-olds was 3.6% (95% CI, 1.9-6.7) and 4.2% (95% CI, 3.1-5.7), respectively (P = .69). In 50- to 54-year-old average-risk individuals from the New Hampshire Colonoscopy Registry, Butterly et al47 reported advanced colorectal neoplasia in 3.6% of 50- to 54-year-olds (compared with 3.7% in 45- to 49-year-olds). Brenner et al48 reported advanced colorectal neoplasia in 6.8% of 50- to 54-year-olds undergoing screening colonoscopy.

Two-Step Screening Modalities

Noncolonoscopic screening approaches (eg, FIT) require a second step (ie, colonoscopy) to complete the screening process when the initial screen is abnormal. Currently, data are limited on the yield of 2-step screening approaches for those under age 50. Levin et al49 reported that of the 10,232 Black individuals between ages 45 and 50 who were offered a FIT, 33.1% completed testing. Of these individuals, 4.0% had an abnormal (ie, positive) FIT, and 85.3% of the individuals with an abnormal FIT completed a colonoscopy. Of those undergoing colonoscopy, 57.8% had any adenoma, 33.6% had an advanced adenoma, and 2.6% were diagnosed with CRC. In comparison, 22.3% of Black individuals ages 51 to 56 completed a FIT, and 4.6% of these individuals had a positive FIT, of which 81.1% completed a colonoscopy. Adenomas were found in 56.7% of those completing colonoscopy, whereas 20.0% had an advanced adenoma and 3.3% had CRC.49 Test characteristics (sensitivity, specificity) of the FIT in this population cannot be determined from this study because not all average-risk individuals underwent colonoscopy.

In a cross-sectional study of 816 average-risk individuals ages 45 to 49 who underwent a FIT-fecal DNA testing and colonoscopy, no participants were diagnosed with CRC and 49 (6.0%) had an advanced neoplasm (defined as an advanced adenoma or advanced serrated polyp/lesion, which included lesions ≥1 cm or with cytologic dysplasia).50 Of the 53 of 816 (6.5%) who had a positive FIT-fecal DNA test, 16 (30.2%) had an advanced neoplasm. Of all 49 participants who had an advanced precancerous lesion on colonoscopy, 16 had an abnormal FIT–fecal DNA; thus, FIT–fecal DNA has a sensitivity of 32.7% for detection of an advanced neoplasm. This study was limited by small sample size, and no CRCs were detected. Currently, no data are available data on the yield of other 2-step screening tests, such as CT colonography, flexible sigmoidoscopy, capsule colonoscopy, or Septin9 assay (Epigenomics, San Diego, CA).


Although there are no CRC screening safety data for average-risk individuals <50, there are ample data that colonoscopy for other indications (screening based on family history, symptom evaluation, etc) is safer when comparing younger versus older individuals.51 No controlled studies have assessed the impact of screening on CRC incidence, CRC-related mortality, or the risks and costs of CRC screening versus no screening in individuals under age 50. The Cancer Intervention and Surveillance Modeling Network uses 3 independently developed microsimulation models that incorporate available data to predict life-years gained, CRC incidence and mortality, number of screening tests required, and adverse events of screening for a variety of different screening strategies.52-54 These models are Microsimulation Screening Analysis (Erasmus University Medical Center and Memorial Sloan Kettering Cancer Center), Simulation Model of Colorectal Cancer (University of Minnesota and Massachusetts General Hospital), and Colorectal Cancer Simulated Population model for Incidence and Natural history (RAND Corporation). Results from these models have informed U.S. Preventative Services Task Force guidelines on CRC screening since 2008.55,56 Incorporating the changing epidemiology of EAO-CRC reviewed above, an update of the modeling report by the Cancer Intervention and Surveillance Modeling Network drafted in 2020 compared outcomes for different screening tests (colonoscopy, FIT, FIT–fecal DNA, flexible sigmoidoscopy, and CT colonography) at different intervals and at different starting and stopping ages.57 Although the incidence and mortality rates used in this updated report encompassed all colorectal tumors (adenocarcinoma and neuroendocrine),15 as pointed out by Fields et al58 and reviewed above, the 40- to 49-year-old group was largely unaffected by isolating adenocarcinomas from neuroendocrine tumors. This report compared outcomes associated with screening initiated at ages 45, 50, or 55 and found that of the 57 screening strategies that were considered efficient, most (47/57) began average-risk screening at age 45.57 For every 1,000 individuals screened starting at age 45 versus 50, all 3 models showed a favorable balance of life-years gained compared with adverse events (Table 3). It is important to note that these models assume 100% compliance.

Table 3.
Table 3.:
Life-years gained, additional colonoscopies required, and adverse events of screening per 1,000 individuals screened at ages 45-75 compared with ages 50-75

Ladabaum et al59 demonstrated that starting CRC screening at age 45 would cost $33,900 or $7,700 per quality-adjusted life-year (QALY) for colonoscopy every 10 years and annual FIT screening, respectively. This study also explored hybrid screening options and found that a 1-time flexible sigmoidoscopy at age 45 and then colonoscopy at ages 50 to 75 would cost $55,900 per QALY and an annual FIT from ages 45 to 49 followed by a colonoscopy at ages 50 to 75 would cost $2,500 per QALY. This study did not compare other screening modalities such as CT colonography or FIT–fecal DNA. Azad et al60 reported cost-effectiveness over a 10-year time horizon of single-episode screening at age 40 versus age 50 and found that all modalities were cost-effective against a $50,000 per QALY willingness to pay threshold but that FIT–fecal DNA had the highest cost per QALY.


There are no randomized or observational studies after 2017 that enrolled individuals over age 75 to inform the appropriate time to stop CRC screening. In our search, of 37 relevant article, only 1 presented primary data for when to stop screening.61 In a 2021 simulation study using the Microsimulation Screening Analysis model and considering only FIT screening, several groups appeared to benefit from screening after age 74.61 For example, women without a history of screening and no comorbidities benefitted from annual FIT screening until age 90, whereas unscreened men with or without comorbidities benefited from annual FIT screening until age 88. Conversely, screening was not beneficial beyond age 66 in men or women with severe comorbidities (defined as at least 1 of the following: AIDS, chronic obstructive pulmonary disease, cirrhosis, chronic hepatitis, chronic renal failure, dementia, congestive heart failure, or combinations of at least 1 moderate condition [peripheral vascular disease or cerebrovascular disease paralysis] with any mild [myocardial infarction, ulcer, or rheumatologic disease] or moderate condition). The study used Canadian data on CRC incidence and stage distribution and did not evaluate an optimal age to stop screening with colonoscopy.61

Given the paucity of new data, the decision to screen a patient between ages 76 and 85 remains individualized based on the balance of benefits and harms and individual patient clinical factors and preferences. The risk of advanced colorectal polyps and CRC increases with age.62-64 However, prevalence of medical comorbidities and overall mortality also increase with advancing age.65 Previous guidelines have recommended continuation of screening until at least age 75 when clinically appropriate52,57,66,67; however, only limited randomized or modeling data support the continuation of screening beyond age 75 among those who have received previous screening.57,68 Individuals without a history of prior screening may benefit the most in this setting.57,69 Thus, the decision to initiate or continue screening after age 75 should involve a shared decision-making process between a patient and provider that considers prior screening history, life expectancy, CRC risk, and patient preferences. Patients emphasize provider trust, perceived health risk, barriers to screening tests, and perceived CRC risk in this decision process.70

Individuals ages 86 and older should not be offered CRC screening. Overall mortality risk and risk of adverse events associated with colonoscopy outweigh the life expectancy benefit of polypectomy for this age group.55,61,71 The primary method for CRC prevention through colonoscopy is the removal of high-risk colorectal polyps, and there is considerable lag time in the progression of a precancerous polyp to malignancy and CRC-related death.72 Thus, elderly individuals are more likely to die of natural causes than CRC, and screening provides minimal life expectancy gains beyond mean U.S. life expectancy. In addition, unintended harms from screening are higher in elderly populations and include direct adverse events from colonoscopy (eg, GI hemorrhage, perforation) and indirect adverse events related to the procedure (eg, cardiopulmonary events, unnecessary medical evaluation for findings).73 In the 1 study published since 2017 evaluating screening risk, emergency services utilization and hospitalizations after colonoscopy were found to be significantly higher when age is greater than 75 than when age is 50 to 75.74


Although there are no clinical data on the impact of CRC screening in individuals under age 50 on CRC incidence or CRC-related mortality, there are sufficient supportive data for the MSTF to suggest average-risk CRC screening begin at age 45. As outlined in detail above, this recommendation is supported by the following:

  • Increasing CRC incidence and mortality, such that incidence rates for 45- to 49-year-olds now matches incidence in populations that are already eligible for average-risk screening. Incidence in 45- to 49-year-olds is similar to the incidence observed in 50-year-olds in 1992 when CRC screening was first recommended for those ages 50 and older. Incidence in all 45- to 49-year-olds is currently similar to incidence in Black Americans ages 45 to 49, for whom the MSTF recommended average-risk screening in 2017.
  • Emerging data show that the rate of advanced colorectal neoplasia in average-risk individuals ages 45 to 49 is similar to advanced neoplasia rates observed in screening cohorts of those ages 50 to 59.
  • Modeling studies that show benefits of screening outweigh harms in average-risk 45-49 year olds. Although not specific to a screening population, data show that colonoscopy is safe in 45- to 49-year-olds.
  • Modeling studies demonstrate acceptable cost-effectiveness of average-risk screening to start at age 45.

The MSTF weighed additional factors when issuing this recommendation. As was outlined in the 2017 screening document, the MSTF emphasizes that in addition to early detection of CRC, detection and removal of advanced precancerous polyps is an important target in screening, with the goal of cancer prevention. The similar rates of advanced neoplasia and somatic/molecular features of CRC in 45- to 49-year-olds compared with ≥50-year-olds suggests that the screening target is the same. Although data quantifying the impact of screening under age 50 are currently lacking, a potential advantage is reduction in CRC incidence for those 50 and older via colonoscopic polypectomy. This may be of particular benefit in the context of the observed birth cohort effect, where CRC risk appears to accumulate across the life course. CRC is diagnosed at later stages in individuals under age 50 compared with those over 50 and results in substantial life-years lost. As reviewed by Siegel et al,75 young CRC patients face unique issues, such as financial toxicity (including material [eg, trouble paying bills], psychological [eg, worrying about paying bills], and behavioral [eg, skipping medications] financial hardships) for those who are in their prime of earning potential, sexual health and fertility concerns, and long-term survivorship. Our recommendation to consider screening in those ages 45 to 49 does not detract from the critical importance of continued efforts to improve screening in those over age 50, where the reported prevalence of screening in individuals ages 50 to 54 years, 55 to 54 years, and ≥65 years is only 48%, 68%, and 71%,76 respectively, and even lower among those of lower socioeconomic status.77

Our recommendation is in congruence with emerging recommendations from other professional societies who are also supporting average-risk CRC screening starting at age 45 on a qualified basis (Table 4). Currently, data are insufficient to guide whether a specific modality of screening is preferred for this age cohort, whether a hybrid approach should be used, or whether screening intervals should be customized.

Table 4.
Table 4.:
Summary of professional society recommendations on when to start and when to stop CRC screening

MSTF recommendations on when to stop screening remain unchanged given a lack of new evidence to alter current practice. For individuals ages 76 to 85, the decision to start or continue screening should be individualized. Important considerations include prior screening history, life expectancy, CRC risk, and personal preference, prompting the need for shared decision-making with providers to weigh the risks and benefits of screening. CRC screening is not recommended after age 85.


Although there are many unanswered questions about the etiology, risk factors, and treatment approaches for EAO-CRC, key areas where data are needed to further refine screening guidelines are outlined in Table 5. At present, it is unclear whether all individuals ages 45 and older should undergo CRC screening or whether a precision-screening approach, using a combination of polygenic factors, environmental and lifestyle exposures, and prior screening, is preferred. Data are needed to inform the best screening tools that can optimize yield, efficacy, cost, access, individual, and provider preferences. Data are needed to assess the efficacy and acceptability of a hybrid screening approach, for instance where noninvasive screening is offered at younger ages and colonoscopy is offered as age-related risk increases. As screening expands to younger individuals, it will be critically important to establish systems that track and ensure equitable access to under-represented populations. Although data shows that the United States has sufficient colonoscopy capacity to support expanding screening to 45- to 49-year-olds with colonoscopy either as a primary or follow-up test,78 it is unclear whether colonoscopy access is equitable. It is also unclear whether the established screening and neoplasia surveillance intervals should be the same in younger individuals as they are in older individuals. Finally, data on whether primary prevention interventions in early adulthood, such as chemoprevention or dietary/lifestyle changes, are needed to assess impact on long-term cancer risk.

Table 5.
Table 5.:
Areas of future work to refine recommendations on when to start and stop CRC screening

When to stop screening also warrants further research. Currently, patients and providers rely on few data elements to determine when there are no longer benefits of screening. Longitudinal trials that follow CRC and other health outcomes for screened participants until the time of death will better inform strategies. However, such studies require decades and are less feasible than microsimulation models or risk stratification strategies that can also inform appropriate and safe use of screening for elderly populations. Approaches to screening test modalities have also been understudied in populations over age 75.


S. G. P.: Research support from Olympus America, research support from Freenome Inc, and honorarium from ERBE USA Inc. F. P. M.: Consultant for Freenome Inc, consultant for Bayer Pharmaceuticals, and consultant for Owl Peak Labs. C. A. B.: Research support from Ferring Pharmaceuticals Inc, Janssen Pharmaceuticals, Cancer Prevention Pharmaceuticals, Emtora Biosciences, and Freenome Inc., advisor for SLA Pharmaceuticals and Freenome Inc. J. A. D.: Spouse is Medical Director of Premera Blue Cross. S. A. G.: Consultant for Olympus America, Microtech, Cook, and Motus GI. B. C. J.: Advisory board for Motus GI. A. S.: Scientific Consultant for Freenome Inc and Iterative Scopes Inc. D. J. R.: Advisory board for Freenome Inc and Amadix. All other authors disclosed no financial relationships. The contents do not represent the views of the Veterans Administration or the United States Government.


We thank Lilian Hoffecker, PhD, MLS, and Kristen DeSanto, MSLS, research librarians from the Strauss Health Sciences Library at University of Colorado, and Bethany Myers, MSLIS, research informationist at the UCLA Louise M. Darling Biomedical Library for assistance with the literature search. We thank Jennifer M. Kolb, MD, MS, at the University of California, Irvine, who assisted with citation review. We thank Eric Montminy, MD (Tulane University), Jordan Karlitz, MD (Denver Health and Hospital Authority), and Meijiao Zhou, PhD, MPH (Fresenius Medical Care North America), for their work in SEER data extraction, analysis, and presentation for Figure 1.

Abbreviations: CMS, consensus molecular subtype; CRC, colorectal cancer; EAO-CRC, early-age onset colorectal cancer; FIT, fecal immunochemical test; GRADE, Grading of Recommendations Assessment, Development and Evaluation; LAO-CRC, later-age onset colorectal cancer MSTF, U.S. Multi-Society Task Force; QALY, quality-adjusted life-year; SEER, Surveillance, Epidemiology, and End Results


1. Winawer SJ, Fletcher RH, Miller L, et al. Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology 1997;112:594–642.
2. Rex DK, Boland CR, Dominitz JA, et al. Colorectal cancer screening: recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer. Gastroenterology 2017;153:307–323.
3. Gupta S, Lieberman D, Anderson JC, et al. Recommendations for follow-up after colonoscopy and polypectomy: a consensus update by the US Multi-Society Task Force on colorectal cancer. Gastroenterology 2020;158:1131–1153.
4. Kahi CJ, Boland CR, Dominitz JA, et al. Colonoscopy surveillance after colorectal cancer resection: recommendations of the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology 2016;150:758–768.
5. Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin 2020;70:145–164.
6. Edwards BK, Noone AM, Mariotto AB, et al. Annual report to the nation on the status of cancer, 1975-2010, featuring prevalence of comorbidity and impact on survival among persons with lung, colorectal, breast, or prostate cancer. Cancer 2014;120:1290–1314.
7. Brenner H, Chen C. The colorectal cancer epidemic: challenges and opportunities for primary, secondary and tertiary prevention. Br J Cancer 2018;119:785–792.
8. Siegel RL, Miller KD, Fedewa SA, et al. Colorectal cancer statistics, 2017. CA Cancer J Clin 2017;67:177–193.
9. Siegel RL, Fedewa SA, Anderson WF, et al. Colorectal cancer incidence patterns in the United States, 1974-2013. J Natl Cancer Inst 2017;109:djw322.
10. Patel SG, Boland CR. Colorectal cancer in persons under age 50: seeking causes and solutions. Gastrointest Endosc Clin North Am 2020;30:441–455.
11. Patel SG, Boland CR. Genetic testing use and expectations in early onset colorectal cancer. Curr Treatm Opt Gastroenterol 2020;18:589–603.
12. Stoffel EM, Murphy CC. Epidemiology and mechanisms of the increasing incidence of colon and rectal cancers in young adults. Gastroenterology 2019;158:341–353.
13. Bhandari A, Woodhouse M, Gupta S. Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers. J Invest Med 2017;65:311–315.
14. Siegel RL, Medhanie GA, Fedewa SA, et al. State variation in early-onset colorectal cancer in the United States, 1995-2015. J Natl Cancer Inst 2019;111:1104–1106.
15. Montminy EM, Zhou M, Maniscalco L, et al. Contributions of adenocarcinoma and carcinoid tumors to early-onset colorectal cancer incidence rates in the United States. Ann Intern Med 2021;174:157–166.
16. SEER stat database incidence. Volume 2021. Available at: Accessed February 14, 2021.
17. Lin JS, Perdue LA, Henrikson NB, et al. Screening for colorectal cancer: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA 2021;325:1978–1997.
18. Bailey CE, Hu CY, You YN, et al. Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010. JAMA Surg 2015;150:17–22.
19. Centers for Disease Control and Prevention, National Center for Health Statistics. Underlying cause of death 1999-2019 on CDC WONDER online database, released in 2020. Data are from the multiple cause of death files, 1999-2019, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Available at: Accessed May 13, 2021.
20. Murphy CC, Wallace K, Sandler RS, et al. Racial disparities in incidence of young-onset colorectal cancer and patient survival. Gastroenterology 2019;156:958–965.
21. Siegel RL, Miller KD, Jemal A. Colorectal cancer mortality rates in adults aged 20 to 54 years in the United States, 1970-2014. JAMA 2017;318:572–574.
22. Holowatyj AN, Ruterbusch JJ, Rozek LS, et al. Racial/ethnic disparities in survival among patients with young-onset colorectal cancer. J Clin Oncol 2016;34:2148–2156.
23. Dozois EJ, Boardman LA, Suwanthanma W, et al. Young-onset colorectal cancer in patients with no known genetic predisposition: can we increase early recognition and improve outcome? Medicine (Baltimore) 2008;87:259–263.
24. Chen FW, Sundaram V, Chew TA, et al. Advanced-stage colorectal cancer in persons younger than 50 years not associated with longer duration of symptoms or time to diagnosis. Clin Gastroenterol Hepatol 2017;15:728–737.
25. Abdelsattar ZM, Wong SL, Regenbogen SE, et al. Colorectal cancer outcomes and treatment patterns in patients too young for average-risk screening. Cancer 2016;122:929–934.
26. Teng A, Lee DY, Cai J, et al. Patterns and outcomes of colorectal cancer in adolescents and young adults. J Surg Res 2016;205:19–27.
27. Georgiou A, Khakoo S, Edwards P, et al. Outcomes of patients with early onset colorectal cancer treated in a UK specialist cancer center. Cancers (Basel) 2019;11:1558.
28. Liang JT, Huang KC, Cheng AL, et al. Clinicopathological and molecular biological features of colorectal cancer in patients less than 40 years of age. Br J Surg 2003;90:205–214.
29. Chang DT, Pai RK, Rybicki LA, et al. Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features. Mod Pathol 2012;25:1128–1139.
30. You YN, Xing Y, Feig BW, et al. Young-onset colorectal cancer: is it time to pay attention? Arch Intern Med 2012;172:287–289.
31. Pearlman R, Frankel WL, Swanson B, et al. Prevalence and spectrum of germline cancer susceptibility gene mutations among patients with early-onset colorectal cancer. JAMA Oncol 2017;3:464–471.
32. Stoffel EM, Koeppe E, Everett J, et al. Germline genetic features of young individuals with colorectal cancer. Gastroenterology 2018;154:897–905.
33. Lieu CH, Golemis EA, Serebriiskii IG, et al. Comprehensive genomic landscapes in early and later onset colorectal cancer. Clin Cancer Res 2019;25:5852–5858.
34. Guinney J, Dienstmann R, Wang X, et al. The consensus molecular subtypes of colorectal cancer. Nat Med 2015;21:1350–1356.
35. Willauer AN, Liu Y, Pereira AAL, et al. Clinical and molecular characterization of early-onset colorectal cancer. Cancer 2019;125:2002–2010.
36. Abualkhair WH, Zhou M, Ochoa CO, et al. Geographic and intra-racial disparities in early-onset colorectal cancer in the SEER 18 registries of the United States. Cancer Med 2020;9:9150–9159.
37. Imperiale TF, Wagner DR, Lin CY, et al. Results of screening colonoscopy among persons 40 to 49 years of age. N Engl J Med 2002;346:1781–1785.
38. Rundle AG, Lebwohl B, Vogel R, et al. Colonoscopic screening in average-risk individuals ages 40 to 49 vs 50 to 59 years. Gastroenterology 2008;134:1311–1315.
39. Friedenberg FK, Singh M, George NS, et al. Prevalence and distribution of adenomas in black Americans undergoing colorectal cancer screening. Dig Dis Sci 2012;57:489–495.
40. Lieberman DA, Williams JL, Holub JL, et al. Colonoscopy utilization and outcomes 2000 to 2011. Gastrointest Endosc 2014;80:133–143.
41. Eberth JM, Thibault A, Caldwell R, et al. A statewide program providing colorectal cancer screening to the uninsured of South Carolina. Cancer 2018;124:1912–1920.
42. Hong SN, Kim JH, Choe WH, et al. Prevalence and risk of colorectal neoplasms in asymptomatic, average-risk screenees 40 to 49 years of age. Gastrointest Endosc 2010;72:480–489.
43. Lee SE, Jo HB, Kwack WG, et al. Characteristics of and risk factors for colorectal neoplasms in young adults in a screening population. World J Gastroenterol 2016;22:2981–2992.
44. Hong W, Dong L, Stock S, et al. Prevalence and characteristics of colonic adenoma in mainland China. Cancer Manag Res 2018;10:2743–2755.
45. Panteris V, Vasilakis N, Demonakou M, et al. Alarming endoscopic data in young and older asymptomatic people: results of an open access, unlimited age colonoscopic screening for colorectal cancer. Mol Clin Oncol 2020;12:179–185.
46. Kolb JM, Hu J, DeSanto K, et al. Early-age onset colorectal neoplasia in average risk individuals undergoing screening colonoscopy: a systematic review and meta-analysis. Gastroenterology. 2021. Epub 2021 Jun 10.
47. Butterly LF, Siegel RL, Fedewa S, et al. Colonoscopy outcomes in average-risk screening equivalent young adults: data from the New Hampshire Colonoscopy Registry. Am J Gastroenterol 2021;116:171–179.
48. Brenner H, Zwink N, Ludwig L, et al. Should screening colonoscopy be offered from age 50? Dtsch Arztebl Int 2017;114:94–100.
49. Levin TR, Jensen CD, Chawla NM, et al. Early screening of African Americans (45-50 years old) in a fecal immunochemical test-based colorectal cancer screening program. Gastroenterology 2020;159:1695–1704.
50. Imperiale TF, Kisiel JB, Itzkowitz SH, et al. Specificity of the multi-target stool DNA test for colorectal cancer screening in average-risk 45-49 year-olds: a cross-sectional study. Cancer Prev Res 2021;14:489–496.
51. Kothari ST, Huang RJ, Shaukat A, et al. ASGE review of adverse events in colonoscopy. Gastrointest Endosc 2019;90:863–876.
52. Wolf AMD, Fontham ETH, Church TR, et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin 2018;68:250–281.
53. Peterse EFP, Meester RGS, Siegel RL, et al. The impact of the rising colorectal cancer incidence in young adults on the optimal age to start screening: microsimulation analysis I to inform the American Cancer Society colorectal cancer screening guideline. Cancer 2018;124:2964–2973.
54. Knudsen AB, Zauber AG, Rutter CM, et al. Estimation of benefits, burden, and harms of colorectal cancer screening strategies: modeling study for the US Preventive Services Task Force. JAMA 2016;315:2595–2609.
55. Bibbins-Domingo K, Grossman DC, Curry SJ, et al. Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA 2016;315:2564–2575.
56. USPSTF. Screening for colorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2008;149:627–637.
57. Colorectal cancer screening: a decision analysis for the U.S. Preventive Services Task Force. Volume 2021. Available at: Accessed April 9, 2021.
58. Fields PM Jr., Butterly LF, Anderson JC. Inclusion of carcinoids in early onset colorectal tumor incidence rates: adenocarcinoma in young adults still the major problem. Gastroenterology 2021;60:2613–2615.
59. Ladabaum U, Mannalithara A, Meester RGS, et al. Cost-effectiveness and national effects of initiating colorectal cancer screening for average-risk persons at age 45 years instead of 50 years. Gastroenterology 2019;157:137–148.
60. Azad NS, Leeds IL, Wanjau W, et al. Cost-utility of colorectal cancer screening at 40 years old for average-risk patients. Prev Med. 2020. Epub 2020 Jan 27.
61. Cenin DR, Tinmouth J, Naber SK, et al. Calculation of stop ages for colorectal cancer screening based on comorbidities and screening history. Clin Gastroenterol Hepatol 2021;19:547–555.
62. Pinsky PF, Schoen RE. Colorectal cancer incidence by age among patients undergoing surveillance colonoscopy. JAMA Intern Med 2015;175:858–860.
63. Martinez ME, Baron JA, Lieberman DA, et al. A pooled analysis of advanced colorectal neoplasia diagnoses after colonoscopic polypectomy. Gastroenterology 2009;136:832–841.
64. Calderwood AH, Holub JL, Greenwald DA, et al. Yield and practice patterns of surveillance colonoscopy among older adults: an analysis of the GI Quality Improvement Consortium. Am J Gastroenterol 2019;114:1811–1819.
65. Garcia-Albeniz X, Hsu J, Bretthauer M, et al. Effectiveness of screening colonoscopy to prevent colorectal cancer among Medicare beneficiaries aged 70 to 79 years: a prospective observational study. Ann Intern Med 2017;166:18–26.
66. NCCN. Colorectal cancer screening guidelines. Available at: Accessed April 1, 2021.
67. Shaukat A, Kahi CJ, Burke CA, et al. ACG clinical guidelines: colorectal cancer screening 2021. Am J Gastroenterol 2021;116:458–479.
68. Zauber A, Knudsen A, Rutter CM, et al. Evaluating the benefits and harms of colorectal cancer screening strategies: a collaborative modeling approach. AHRQ publication no. 14-05203-EF-2. Rockville, MD: Agency for Healthcare Research and Quality; 2015.
69. Lansdorp-Vogelaar I, Gulati R, Mariotto AB, et al. Personalizing age of cancer screening cessation based on comorbid conditions: model estimates of harms and benefits. Ann Intern Med 2014;161:104–112.
70. Piper MS, Maratt JK, Zikmund-Fisher BJ, et al. Patient attitudes toward individualized recommendations to stop low-value colorectal cancer screening. JAMA Netw Open 2018;1:.
71. Lin OS, Kozarek RA, Schembre DB, et al. Screening colonoscopy in very elderly patients: prevalence of neoplasia and estimated impact on life expectancy. JAMA 2006;295:2357–2365.
72. Chung DC. The genetic basis of colorectal cancer: insights into critical pathways of tumorigenesis. Gastroenterology 2000;119:854–865.
73. Ko CW, Sonnenberg A. Comparing risks and benefits of colorectal cancer screening in elderly patients. Gastroenterology 2005;129:1163–1170.
74. Grossberg LB, Papamichael K, Leffler DA, et al. Patients over age 75 are at increased risk of emergency department visit and hospitalization following colonoscopy. Dig Dis Sci 2020;65:1964–1970.
75. Siegel RL, Jakubowski CD, Fedewa SA, et al. Colorectal cancer in the young: epidemiology, prevention, management. Am Soc Clin Oncol Educ Book 2020;40:1–14.
76. Joseph DA, King JB, Dowling NF, et al. Vital signs: colorectal cancer screening test use—United States, 2018. MMWR Morb Mortal Wkly Rep 2020;69:253–259.
77. Henley SJ, Thomas CC, Lewis DR, et al. Annual report to the nation on the status of cancer, part II: progress toward Healthy People 2020 objectives for 4 common cancers. Cancer 2020;126:2250–2266.
78. Joseph DA, Meester RG, Zauber AG, et al. Colorectal cancer screening: estimated future colonoscopy need and current volume and capacity. Cancer 2016;122:2479–2486.
79. Myers EA, Feingold DL, Forde KA, et al. Colorectal cancer in patients under 50 years of age: a retrospective analysis of two institutions' experience. World J Gastroenterol 2013;19:5651–5657.
80. Dharwadkar P, Greenan G, Singal AG, et al. Is colorectal cancer in patients younger than 50 years of age the same disease as in older patients? Clin Gastroenterol Hepatol 2021;19:192–194.
    81. Rho YS, Gilabert M, Polom K, et al. Comparing clinical characteristics and outcomes of young-onset and late-onset colorectal cancer: an international collaborative study. Clin Colorectal Cancer 2017;16:334–342.
    82. Scott RB, Rangel LE, Osler TM, et al. Rectal cancer in patients under the age of 50 years: the delayed diagnosis. Am J Surg 2016;211:1014–1018.
    83. Strum WB, Boland CR. Clinical and genetic characteristics of colorectal cancer in persons under 50 years of age: a review. Dig Dis Sci 2019;54:3059–3065.
      84. Wang R, Wang MJ, Ping J. Clinicopathological features and survival outcomes of colorectal cancer in young versus elderly: a population-based cohort study of SEER 9 Registries data (1988-2011). Medicine (Baltimore) 2015;94:e1402.
      85. Eisele R, Vogelsang E, Kraft K, et al. Screening for colorectal lesions with high-resolution video colonoscopes in a German male average-risk population at 40 to 59 years of age. Zeitschr Gastroenterol 2007;45:952–957.
        86. Park HW, Byeon JS, Yang SK, et al. Colorectal neoplasm in asymptomatic average-risk Koreans: the KASID prospective multicenter colonoscopy survey. Gut Liver 2009;3:35–40.
        87. Wang FW, Hsu PI, Chuang HY, et al. Prevalence and risk factors of asymptomatic colorectal polyps in Taiwan. Gastroenterol Res Pract 2014;2014:985205.
          88. Hemmasi G, Sohrabi M, Zamani F, et al. Prevalence of colorectal adenoma in an average-risk population aged 40-50 versus 50-60 years. Eur J Cancer Prevent 2015;24:386–390.
            89. Leshno A, Moshkowitz M, David M, et al. Prevalence of colorectal neoplasms in young, average risk individuals: a turning tide between East and West. World J Gastroenterol 2016;22:7365–7372.
            90. USPSTF, Davidson KW, Barry MJ, et al. Screening for colorectal cancer: US Preventive Services Task Force recommendation statement. JAMA 2021;325:1965–1977.
            91. Qaseem A, Crandall CJ, Mustafa RA, et al. Screening for colorectal cancer in asymptomatic average-risk adults: a guidance statement from the American College of Physicians. Ann Intern Med 2019;171:643–654.
            92. Jung YS, Ryu S, Chang Y, et al. Risk factors for colorectal neoplasia in persons aged 30 to 39 years and 40 to 49 years. Gastrointest Endosc 2015;81:637–645.e7.
            93. Chang LC, Wu MS, Tu CH, et al. Metabolic syndrome and smoking may justify earlier colorectal cancer screening in men. Gastrointest Endosc 2014;79:961–969.
            94. Ionescu EM, Nicolaie T, Gologan SI, et al. Opportunistic colorectal cancer screening using colonoscopy. Comparative results between two historical cohorts in Bucharest, Romania. J Gastrointest Liver Dis 2015;24:171–176.
              © 2021 by The American College of Gastroenterology, the American Society for Gastrointestinal Endoscopy, and the AGA Institute.