S14 Trends in Pancreatic Cancer, 2004-2014 Nationwide Inpatient Retrospective Cohort Study

Introduction:

Pancreatic cancer is the fourth most frequent cause of cancer death after lung, breast/prostate, and colorectal cancer. Although it is one of the leading causes of cancer death, only a few studies have evaluated population-based trends in diagnosis, average age, hospitalization mortality rate, and total hospital charges.

Methods:

A retrospective analysis utilizing the de-identified data from the National Inpatient Sample (NIS) was used to analyze patients hospitalized with pancreatic cancer as a primary admission diagnosis from 2004 through 2014. Hospital encounters for pancreas cancer were identified using the International Classification of Diseases (ICD-9) diagnostic codes; '157.9' '157.4' '156.2' '157.0' '157.1' '157.2' '157.3' '157.4. The NIS is a component of the Healthcare Cost and Utilization Project, a national health care database developed through a partnership among federal and state governments and health care institutions sponsored by the Agency for Healthcare Research and Quality. We extracted the average age, length of stay, in-hospital mortality rate, and average total hospital charges. All were demonstrated through the graphs to show the trends.

Results:

A total of 177763 hospitalizations of pancreatic cancer were identified from 2004 to 2014 nationwide inpatient sample. The mortality rate of in-hospital admissions decreased consistently (from 12.2% in 2004 to 7.61% in 2014), while the average total hospitalization charges continued to increase (33,600 US Dollars in 2004 vs 59,113 US dollars in 2014), without significant changes in the average age of admissions (68.5 years in 2004 vs 67.7 years in 2014). Slight trending down could be noticed in the average length of stay (7.82 days in 2004 vs 6.37 days in 2014).

Conclusion:

A large database was used for trending temporal changes of hospitalization data and survival of patients with pancreatic adenocarcinoma. Our analysis showed downward trends in Length of stay and in-hospital mortality rate. The average total hospital charges continued to trend up, without significant change in the average age of admissions.

Figure 1.: Trending graphs of Pancreatic Cancer by the Letters: A) Average age of individuals hospitalized with pancreatic cancer from 2004 to 2014. B) Average Length of Stay for all pancreatic cancer discharges between 2004 and 2014. C) Estimates of Average total charges for pancreatic cancer discharges between 2004 and 2014. D) Mortality rate of individuals with hospital admissions of Pancreatic Cancer between 2004-2014.