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Intake of Dietary Fiber, Fruits, and Vegetables and Risk of Diverticulitis

Ma, Wenjie MBBS, ScD1,2; Nguyen, Long H. MD, MS1,2; Song, Mingyang MD, ScD1,2,3; Jovani, Manol MD, MPH1,2; Liu, Po-Hong MD, MPH1,2; Cao, Yin ScD, MPH1,4; Tam, Idy MD, MS5; Wu, Kana MD, PhD3; Giovannucci, Edward L. MD, ScD3,6,7; Strate, Lisa L. MD, MPH8; Chan, Andrew T. MD, MPH1,2,7,9

American Journal of Gastroenterology: September 2019 - Volume 114 - Issue 9 - p 1531–1538
doi: 10.14309/ajg.0000000000000363
ARTICLE
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OBJECTIVES: Although low fiber intake has been considered a risk factor for diverticulitis, prospective evidence is limited in women despite having a disproportionate burden of disease, with little known about variation in the protective effects according to food sources. We assessed the associations of intakes of fiber and major food sources of fiber including fruits and vegetables with risk of diverticulitis in a large cohort of women.

METHODS: We followed 50,019 women in the Nurses' Health Study (1990–2014) who were aged 43–70 years and free of diverticulitis, cancer, and inflammatory bowel disease at baseline. Incident diverticulitis was identified through self-report with validity confirmed by review of medical records.

RESULTS: We documented 4,343 incident cases of diverticulitis, encompassing 1,106,402 person-years of follow-up. Compared with participants in the lowest quintile, the multivariable hazard ratio of diverticulitis in the highest quintile of total fiber intake was 0.86 (95% confidence interval: 0.78–0.95; P-trend = 0.002). Fiber from fruits and cereals, but not vegetables, was associated with a decreased risk of diverticulitis. Furthermore, intake of total whole fruit intake and specific fruits such as apples/pears and prunes were associated with reduced risk of diverticulitis with a multivariable hazard ratio for diverticulitis of 0.95 (0.92–0.98; P-trend < 0.001) for every serving increase of total whole fruit intake per day.

DISCUSSION: Higher intake of dietary fiber and fiber from different food sources, except for vegetable fiber, are associated with a lower risk of diverticulitis in women. A greater intake of whole fruit is also associated with reduced risk.

1Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA;

2Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA;

3Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA;

4Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA;

5Tufts University School of Medicine, Boston, Massachusetts, USA;

6Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA;

7Department of Medicine, Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA;

8Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington, USA;

9Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

Correspondence: Andrew T. Chan. E-mail: achan@mgh.harvard.edu.

SUPPLEMENTARY MATERIAL accompanies this paper at http://links.lww.com/AJG/B261

Received December 21, 2018

Accepted July 10, 2019

Online date: August 7, 2019

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INTRODUCTION

Diverticulosis, or the presence of colonic diverticula, is very common in Western countries with prevalence increasing with age, reaching 60% by age 70 (1). The principal complication of diverticulosis is diverticulitis, acute inflammation of diverticula and the surrounding colon, which can lead to significant complications that necessitate colectomy. Diverticulitis is among the leading gastrointestinal indications for hospitalizations and outpatient clinic visits in the United States (2). Growing evidence has linked lifestyle and dietary factors to the etiopathogenesis of diverticulitis (3,4).

Fiber intake is perhaps the most studied dietary risk factor for diverticular disease, a collective term for both clinically significant and symptomatic diverticulosis and diverticulitis. The observations of striking geographical differences and increase after industrialization in the prevalence of diverticular disease have contributed to the belief that fiber intake plays a significant role in its development (5). This hypothesis is supported by findings from our group and others in prospective cohort studies (4,6–9). Furthermore, the protective effects of dietary fiber may vary according to fiber subtypes and food sources (6–8). However, a potential drawback from previous studies is the inability to distinguish between diverticulitis, diverticular bleeding, and symptomatic uncomplicated diverticulosis. Diverticular bleeding and diverticulitis have demonstrated distinct clinical risk factors and etiopathogenesis (10), and 2 recent colonoscopy-based studies have cast doubt on the relationship between a low-fiber diet and diverticulosis (1,11), highlighting the importance of considering diverticulitis separately from other phenotypes of diverticular disease. In addition, most previous studies relied on registry-level data and included hospitalized patients who generally represent more severe cases. We recently reported that adherence to a healthy lifestyle including higher fiber intake was associated with a substantial decrease in the risk of diverticulitis that included both less severe forms of the disease treated in the outpatient setting and more severe cases that led to hospitalization (12). Yet, data on fiber subtypes and diverticulitis are still lacking in women, who experience a disproportionate burden of disease (13–15).

Finally, as major sources of dietary fiber, individual fruits and vegetables vary in fiber content and composition of other nutrients that may affect their beneficial effects. A recent genome-wide association analysis showed that genes associated with diverticular disease shared a common etiology with fresh fruit intake (16), further suggesting a mechanistic link. However, no previous study has examined what types of intake of fruits and vegetables may influence the risk of diverticulitis. Therefore, we conducted a comprehensive, prospective evaluation of dietary fiber and fruit and vegetable intake in relation to risk of diverticulitis in a large cohort of women, the Nurses' Health Study (NHS).

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METHODS

Study population

The NHS is a cohort of 121,700 US female registered nurses aged 30–55 years at enrollment in 1976 (17). Participants have been mailed questionnaires every 2 years since inception, querying demographics, lifestyle factors, medical history, and disease outcomes, with a follow-up rate greater than 90% of available person-time. The study was approved by Institutional Review Boards of Brigham and Women's Hospital. Return of the questionnaires was considered to imply written informed consent.

We excluded participants who reported a diagnosis of diverticulitis, nonmelanoma cancers, or inflammatory bowel disease before baseline in 1990, those who had incomplete information for dietary data, and those who reported implausible total energy intake (<500 or >3,500 kcal/d). After exclusions, a total of 50,019 women were included in the primary analysis (see Supplemental Figure 1, Supplemental Digital Content 1, http://links.lww.com/AJG/B261).

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Dietary assessment

Dietary intake data were assessed through administration of a validated 131-item semi-quantitative food frequency questionnaire (FFQ) every 4 years, in which participants were asked how often they typically consumed each food of a standard portion size during the previous year. We included all whole fruits and all vegetables on the FFQ in our analyses, and fruit juice including apple, orange, grapefruit, and other juice was considered separately because it typically includes added sugar and is associated with an increased risk of adverse health outcomes such as diabetes (18) and greater weight gain (19). Fruits and vegetables with similar culinary usages and nutrient profiles were combined, e.g., apples and pears. We ranked fruits and vegetables by their proportional contributions to total intake of fruit fiber or vegetable fiber based on results from all available FFQs.

Daily intake for each nutrient was calculated by multiplying the reported frequency of each food item by its nutrient content, and then summing across foods. Fiber intake was calculated using the Association of Official Analytical Chemists method (accepted by the US Food and Drug Administration and the Food and Agriculture Organization of the World Health Organization for nutrition labeling purposes) (20). Data on soluble fiber and insoluble fiber were available directly from some manufactures, calculations from ingredients (USDA, personal communication), analysis done by Kellogg's specifically from the Channing laboratory, as well as other dietary fiber food composition data (Horvath and Robertson 1986, USDA 1993) (7). We adjusted fiber intake for total caloric intake using the nutrient residual method (21). Fiber intake from major food sources, including cereals, vegetables, and fruits, was also considered separately. FFQs have shown good reproducibility and validity for assessing intake of fiber, fruits, and vegetables (22,23). With a correction for the ratio of the within-person to the between-person variation, the correlation coefficient comparing diet assessment from FFQ with multiple 7-day dietary records was 0.68 for dietary fiber and ranged from 0.38 (strawberries) to 0.95 (bananas) for individual fruits (median: 0.76) and 0.25 (kale, mustard greens, or chard greens) to 0.73 (lettuce) for individual vegetables (median: 0.46).

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Ascertainment of diverticulitis

Our primary endpoint was diverticulitis requiring antibiotic therapy or hospitalization. As described previously (24,25), follow-up questionnaires in 2008, 2012, and 2014 ascertained using a series of questions diverticulitis requiring antibiotic therapy or hospitalization, diverticular bleeding, and diverticulosis without diverticulitis or diverticular bleeding. This logic structure minimizes misclassification between these entities. If participants reported they ever had a diagnosis of diverticulitis, they were subsequently asked the year of each episode dating back to 1990. In a validation study, we reviewed 107 medical records from women reporting incident diverticulitis, and 88% of the cases were confirmed.

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Assessment of covariates

Participants reported their height at the time of enrollment. At baseline and updated biennially, information on body weight, smoking status, menopausal status and menopausal hormone use, physical examination, and use of multivitamins, aspirin, other nonsteroidal anti-inflammatory drugs (NSAIDs), or acetaminophen were obtained. Body mass index (BMI) was calculated as weight in kilograms divided by height in meters squared. Physical activity was assessed every 2–4 years using validated questionnaires (26). Hypertension and hypercholesterolemia were self-reported, with their validity previously confirmed (27). In our analysis, we allowed covariates to be time-varying using the most recent information.

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Statistical analysis

Person-time was calculated from the date of baseline questionnaire until the date of diagnosis of diverticulitis, death, last follow-up questionnaire, or the end of the study period (June 2014), whichever came first. We censored participants who reported a new diagnosis of gastrointestinal cancer or inflammatory bowel disease at the date of diagnosis. We used simple updating or the most recent dietary information available (i.e., the intake reported on the most recent FFQ at the start of each 2-year follow-up interval). Missing values for a given FFQ were carried forward from previous available assessments.

Participants were categorized into quintiles according to their energy-adjusted fiber intake (28,29). Linear trend was assessed by assigning the median value to each category and modeling this as a continuous variable. Using Cox proportional hazards regression with time-varying dietary intake and covariates, we estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Proportional hazards assumption was evaluated by testing the significance of the interaction term between exposure and age by using the Wald test, and no violation of the proportional hazards assumption was observed (P for interaction > 0.05).

We stratified the analysis jointly by age at the start of follow-up and calendar time of the current questionnaire cycle to control for confounding by age, calendar time, and any possible 2-way interactions between these 2 timescales. In a multivariate analysis, we adjusted for BMI, menopausal status and menopausal hormone use, vigorous physical activity (METs ≥ 6, including jogging, running, bicycling, swimming, tennis, squash or racquetball, rowing, and heavy outdoor work), alcohol intake, smoking, use of aspirin, other NSAIDs, or acetaminophen, multivitamin use, recent physical examination as a proxy for healthcare engagement, hypertension, hypercholesterolemia, calorie intake, and red meat intake. We further controlled for total whole fruit intake for our analysis of individual fruits and total vegetable intake when testing individual vegetables for any independent association.

Statistical analyses were conducted using SAS software version 9.4 (SAS Institute, Cary, NC). All P values are 2-sided and a value <0.05 was considered statistically significant.

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RESULTS

At baseline, women had a mean age of 55 years and an average total fiber intake of 18.0 g. Participant characteristics according to quintiles of energy-adjusted dietary fiber intake are shown in Table 1. Total fiber intake was positively correlated with age, physical activity, multivitamin use, recent history of physical examination, hypercholesterolemia, and diabetes and was inversely correlated with BMI, alcohol intake, acetaminophen use, other NSAID use, and current smoking. Participants who had higher fiber intake tended to consume more fruit, vegetables, and whole grains but less red meat, resulting in a higher healthy eating index score.

Table 1

Table 1

We documented a total of 4,343 incident cases of diverticulitis over 24 years, encompassing 1,106,402 person-years of follow-up. The incidence of diverticulitis in our cohort is similar to other US and European populations (30) taking into consideration that previous population-based studies included only hospitalized events and that the incidence rate is higher in women (13–15). Compared with women in the lowest quintile of total fiber intake, who had a diverticulitis incidence rate of 387 per 100,000 person-years, women in the highest quintile had an incidence rate of 376 per 100,000 person-years, leading to an unadjusted rate difference of 11 fewer cases of diverticulitis in women consuming the most fiber.

In age-adjusted analyses, higher intake of total fiber and fiber from cereals, fruit, and vegetables were each associated with reduced risk of diverticulitis (Table 2). After further adjusting for other risk factors, including red meat intake, the associations between incident diverticulitis and total, cereal, and fruit fiber did not materially change, whereas the association with vegetable fiber was attenuated. Compared with women in the lowest quintile of dietary intake, the multivariable HRs (95% CIs) in the highest quintile were 0.86 (0.78–0.95; P-trend = 0.002) for total fiber, 0.90 (0.81–0.99; P-trend = 0.03) for cereal fiber, 0.83 (0.75–0.92; P-trend < 0.001) for fruit fiber, and 0.92 (0.83–1.01; P-trend = 0.31) for vegetable fiber. Additional adjustment for highest degree received (registered nurse, Bachelors, Masters or Doctorate) as a proxy of socioeconomic status did not change the effect estimates. We then categorized participants according to total fiber intake into 3 groups, <18, 18–25, and ≥25 g/d. The lower cutoff point of 18 g/d was chosen to represent the mean intake of total fiber among participants in our study at baseline, and the higher cutoff of 25 g/d was based on recommended intake for total fiber for adult women (31). Compared with women who consumed total fiber less than 18 g/d, those consuming total fiber of 25 g/d or more had a 13% reduced risk of incident diverticulitis (multivariable HR: 0.87; 95% CI: 0.79–0.96).

Table 2

Table 2

We also found that total whole fruit intake was associated with a reduced risk of diverticulitis (Figure 1). The multivariable HR (95% CI) of diverticulitis was 0.95 (0.92–0.98; P < 0.001) for every serving increase of total whole fruit intake per day. When individual fruits were evaluated, increased intake of apples or pears (HR, 0.85; 95% CI, 0.76–0.96; P = 0.009) and prunes (HR, 0.83; 95% CI, 0.69–0.99; P = 0.04) showed significant associations with lower risk of diverticulitis, independent of total whole fruit intake. In contrast to the inverse association seen for whole fruit, fruit juice was not significantly associated with risk of diverticulitis, with a multivariable HR (95% CI) of 1.04 (0.99–1.08; P-trend = 0.10) for every serving increase of fruit juice per day.

Figure 1

Figure 1

Increased total vegetable intake was not significantly associated with a reduced risk of diverticulitis (HR, 1.00; 95% CI, 0.98–1.02; P = 0.71) (Figure 2). Among individual vegetables, beans or lentils showed a trend toward an inverse association with diverticulitis independent of total vegetable intake, with HR (95% CI) of 0.78 (0.61–1.01; P = 0.06) for every serving increase of intake per day.

Figure 2

Figure 2

Evaluating soluble and insoluble fiber separately, insoluble fiber showed a stronger association with risk of diverticulitis compared with soluble fiber (see Supplemental Table 1, Supplemental Digital Content 1, http://links.lww.com/AJG/B261). Compared with women in the lowest quintile of dietary intake, the multivariable HRs (95% CIs) in the highest quintile were 0.95 (0.86–1.05; P-trend = 0.57) for soluble fiber and 0.86 (0.78–0.95; P-trend = 0.004) for insoluble fiber.

We also separately examined the relationship between consumption of some other processed vegetable foods (that were not accounted into total vegetable intake), including potatoes (baked or mashed), potato chips, and french fries and diverticulitis. We found that after adjusting for other risk factors including fiber intake, intake of baked or mashed potatoes (HR for every serving increase of intake per day: 1.20; 95% CI: 1.07–1.36; P = 0.003), but not french fries (HR: 0.98; 95% CI: 0.63–1.51; P = 0.91) or potato chips (HR: 1.13; 95% CI: 0.96–1.32; P = 0.13) was associated with a modest increase in the risk of diverticulitis.

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DISCUSSION

In a prospective cohort of US women, higher fiber intake was associated with reduced risk of incident diverticulitis. Fiber from fruits and cereals, but not vegetables, was also inversely associated with diverticulitis. In addition, greater consumption of total whole fruit and specific fruits such as apples/pears and prunes was associated with a lower risk of diverticulitis.

The inverse association between fiber intake and diverticulitis is consistent with findings from previous prospective studies. In an earlier analysis using the parallel male cohort, Health Professionals Follow-Up Study (HPFS), over relatively short-term follow-up (1988–1992), Aldoori et al. (6) reported that total fiber intake and fiber from fruit and vegetables, but not cereal, were associated with reduced risk of symptomatic diverticular disease in men. The current study extends our previous investigation in men (12,32) by offering evidence that fiber intake is associated with reduced risk of diverticulitis in women, who experience a disproportionate burden of the disease particularly at older ages (13–15). Crowe et al. (4) confirmed the inverse association between fiber intake and risk of diverticular disease requiring hospitalization or as the cause of death among men and women in the UK-based EPIC-Oxford cohort. It was subsequently demonstrated that a higher intake of dietary fiber, specifically fruit fiber and cereal fiber, was associated with a reduction in the risk of diverticular disease among women (8). However, as noted earlier, these studies are limited by the inability to distinguish between diverticulitis, diverticular bleeding, and symptomatic uncomplicated diverticulosis; additionally, the 2 aforementioned UK studies were based on registry-level data and included only hospitalized patients; the influence of dietary fiber intake on less severe and more common presentations (33) remains unclear.

In contrast to findings from prospective studies of diverticulitis or diverticular disease requiring hospitalization, low intake of dietary fiber was not associated with increased risk of uncomplicated diverticulosis in cross-sectional, colonoscopy-based studies (1,11,34). The divergent associations with diverticulitis and diverticulosis suggest that fiber may not be associated with the development of diverticulosis, but may play a role in preventing the inflammation associated with diverticulitis. Furthermore, data from the colonoscopy-based studies may not be comparable to our findings because diet was assessed after colonoscopy, and patients may have modified their diet because of early symptoms or had differential recall according to the awareness of the disease.

The associations of fruits and vegetables with diverticular disease have also been investigated in other observational studies, but results have been less consistent. In a case-control study conducted in Greece, patients with radiologically confirmed diverticulosis had less frequent consumption of vegetables compared with controls, whereas the frequency of fruit consumption was not significantly different (35). Another case-control study in Taiwan, however, found consumption frequency of fruit and vegetables was not associated with right-sided asymptomatic diverticulosis (36). Although these studies were limited by the retrospective design and small sample size, it is also likely that diverticulosis, in particular right-sided diverticulosis, which is predominant in Asia, has different pathophysiology from left-sided diverticular disease or diverticulitis (37). An earlier analysis from the HPFS cohort demonstrated energy-adjusted associations of symptomatic diverticular disease with some fruits and vegetables, such as romaine or leafy lettuce; peaches, apricots, or plums; oranges; apples; and blueberries (6). Because of high correlations between individual and total fruits or vegetables, it is critical to control for total fruit or vegetable intake in the evaluation of any independent relationship between individual fruits or vegetables and diverticulitis. Our findings indicate that overall intake of fruit may be more important compared with individual items in influencing the risk of diverticulitis. Apples or pears did appear to have the strongest individual associations, but this may reflect that these items were by far the most commonly consumed, contributing to 25.8% of total fruit fiber. Meanwhile, differences in contributions to fiber intake did not appear to account for the association of specific fruits and vegetables with disease risk. It is possible that other nutrients in the individual fruits may play a role in conferring the benefits.

The differences in the associations of fiber subtypes with diverticulitis were also consistent with the literature (8). In parallel with the more pronounced association of fruit fiber and to a lesser extent, cereal fiber, with risk of diverticulitis compared with vegetable fiber, we also observed a stronger association for insoluble vs soluble fiber. Yet, these results should be carefully interpreted because the distribution of total fiber between soluble and insoluble subtypes is dependent on the method of analysis (38). It is also worth noting that although we observed a significant linear trend for total, cereal fiber, and fruit fiber, the HRs were only significant by comparing the highest to the lowest quintile, suggesting a potential threshold of fiber intake for achieving the beneficial effects.

The biological mechanism through which dietary fiber may decrease risk of diverticular disease was initially hypothesized to be mediated by its effects on colonic motility and intraluminal pressure (39,40). More recent evidence suggests that fiber alleviates obesity-induced chronic inflammation and also has weight-unrelated anti-inflammatory effects, the latter of which is likely mediated through intestinal microbiota (41,42). Meanwhile, sex hormones have been shown to alter intestinal permeability (43) and the gut microbiome (44). Previous studies suggested that menopausal hormone therapy was associated with increased risk of diverticular disease in women (4,45). Studies also showed that of the 3 sources of fiber, fruit fiber had the strongest inverse association with circulating concentrations of estradiol, followed by grain fiber; in contrast, vegetable fiber was not associated (46). Taken together, fiber from different food sources may have divergent interactions with sex hormones and gut microbiome that in turn influence risk of diverticulitis in women. However, future investigations are warranted to verify our hypothesis and better understand the potentially varying roles of fiber subtypes and food sources in the development of the disease.

The strengths of our study include the prospective design, detailed and repeated collection of diet and lifestyle information, long-term follow-up, and ascertainment of diverticulitis managed in the inpatient and outpatient setting. Moreover, detailed, contemporaneous information on potential confounders was collected in parallel with fiber, fruit, and vegetable intake.

Several limitations are worth noting. First, the ascertainment of dietary intake and diverticulitis were based on self-report. However, the validity of our dietary instruments has previously been demonstrated (22,23), and confirmation of self-reported diverticulitis is high. Second, the diagnosis of diverticulitis was based on recall among participants who responded to the 2008, 2012, and 2014 questionnaires, which we believe will not result in bias because our outcome is unlikely to be fatal (47). Third, information is lacking on the severity of diverticulitis or whether it was associated with hospitalization. Finally, our cohorts included mostly white health professionals, and future studies in other ethnic groups are needed considering potential ethnic disparities in diverticular disease.

In conclusion, a higher intake of fiber is associated with a lower incidence of diverticulitis. Potential variations exist in the effects of fiber from different food sources. Total whole fruit intake and specific fruits such as apples/pears and prunes are also associated with a reduced risk. Our findings lend support for public health recommendations of maintaining sufficient fiber intake from diet and provide practical dietary guidance for patients in the prevention of diverticulitis.

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CONFLICTS OF INTEREST

Guarantors of the article: Lisa L. Strate, MD, MPH, and Andrew T. Chan, MD, MPH.

Specific author contributions: Lisa L. Strate and Andrew T. Chan contributed equally to this work. W.M., L.L.S., A.T.C.: study concept and design. K.W., E.L.G., L.L.S., and A.T.C.: acquisition of data. W.M.: statistical analysis. All authors: interpretation of data. W.M., L.L.S., and A.T.C.: drafting of the manuscript. All authors: critical revision of the manuscript for important intellectual content.

Financial support: This work was supported by grants UM1 CA186107, R01 DK101495, and K24 DK098311 from the National Institutes of Health. The funders had no role in study design, data collection and analysis, interpretation of data, writing of the report, and decision to submit the paper for publication.

Potential competing interests: A.T.C. receives consulting fees from Janssen, Pfizer, and Bayer Pharma AG for work unrelated to the topic of this manuscript. The remaining authors have no conflicts of interest to disclose.

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Study Highlights

WHAT IS KNOWN

  • ✓ Diverticulitis is a common gastrointestinal indication for hospitalization and outpatient clinic visits.
  • ✓ The impact of fiber intake on diverticulitis is not well understood in women.
  • ✓ Little is known about the variations in the protective effects of fiber according to food sources.
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WHAT IS NEW HERE

  • ✓ Higher fiber intake is associated with a reduced risk of incident diverticulitis in women.
  • ✓ The association may vary according to food sources.
  • ✓ Consumption of total whole fruit and specific fruits are also associated with a reduced risk.
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ACKNOWLEDGEMENTS

The authors thank the participants and staff of the Nurses' Health Study for their valuable contributions.

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