Secondary Logo

Journal Logo

Abstracts: STOMACH

Sentinel Lymph Node Mapping and Biopsy Using Radioactive Tracer in Gastric Cancer


Valizadeh, Neda MD1; Azizi, Shapour MD1; jalaly, Niloufar Yahyapour MD3; Dadvar, Zohreh MD2; Hassanzadeh, Mohsen MD1; Kamani, Fereshteh MD1

Author Information
American Journal of Gastroenterology: October 2012 - Volume 107 - Issue - p S41
doi: 10.1038/ajg.2012.268
  • Free

Purpose: Lymph node metastasis is one of the most important prognostic factors in gastric cancer survival. Sentinel lymph node mapping and biopsy may reduce the extension of lymph node dissection by determination of lymph node involvement. The current study prospectively evaluates the feasibility and reliability of SLN biopsy in gastric cancer.

Methods: A total of 30 patients with gastric cancer with a preoperative imaging stage of T1-T2 or T3, N0 and M0 were enrolled in the study. 4 to 8 hours prior to each operation, 99mTc-sulphur colloid solution (0.5 mL, 2mCi/mL) was endoscopically injected into the submocusal layer around the primary lesion. Lymph nodes were examined using a hand-held gamma probe. Subsequently, a total or subtotal gastrectomy and D2 lymphadenectomy was performed in each patient.

Results: The success rate of SLN biopsy was 100%. Sensitivity, specificity, positive predictive value and negative predictive value were 91.7%, 100%, 100% and 75%, respectively. Both of the two false negative cases were in T3 group. In cases of T2 tumors, the sensitivity was 100%.

Conclusion: SLN biopsy using a gamma probe in early stage gastric cancer seems to be a safe, feasible and accurate procedure with high sensitivity in predicting regional lymph node involvement.

© The American College of Gastroenterology 2012. All Rights Reserved.