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The Polymorphism Interleukin 8-251 A/T Is Associated with Reflux Esophagitis in Heliobacter pylori-Negative Populations

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Ando, Takafumi MD*; El-Omar, Emad MD; Watanabe, Osamu MD; Ohmiya, Naoki MD; Niwa, Yasumasa MD; Goto, Hidemi MD

American Journal of Gastroenterology: September 2008 - Volume 103 - Issue - p S1–S2
Supplement Abstracts Submitted for the 73rd Annual Scientific Meeting of the American College of Gastroenterology: ESOPHAGUS
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Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan, Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen, United Kingdom.

Purpose: Gastro-esophageal reflux disease (GERD) is characterized by increased exposure to gastric acid and interleukin 8-mediated inflammation in the lower esophagus. It is also known that the IL-8-251A/T polymorphism affects IL-8 production. The aim of this study was to determine the association between GERD and IL-8-251A/T polymorphism.

Methods: Three hundred and seventy-two patients with GERD symptoms and 240 asymptomatic controls were studied. Biopsy specimens were obtained from the squamocolumnar junction (SCJ) by upper gastrointestinal endoscopy for histological examination and IL-8 measurement, and IL-8-251A/T polymorphism was genotyped.

Results: Evaluation using the Los Angeles Classification System identified 232 patients (62%) in the GERD group with reflux esophagitis (Grade A: 144, Grade B: 67, Grade C: 20, Grade D: 1) compared to 32 (13%) in the control group (Grade A: 24, Grade B: 8) (P < 0.01). GERD patients had significantly higher IL-8 mucosal levels than the controls (P < 0.01). IL-8-251A/T polymorphism was significantly correlated with both IL-8 mucosal levels at the SCJ and the incidence of reflux esophagitis in the H. pylori-negative population.

Conclusion: The risk of reflux esophagitis is associated with a genetic factor, namely the IL-8-251A/T polymorphism. This association is more important in H. pylori-negative subjects.

© The American College of Gastroenterology 2008. All Rights Reserved.