A Novel Test of Esophageal Function during Meal Consumption 76Wilson, Jason MD; Mainie, I. MRCP; Hila, A. MD; Tutuian, R. MD; Agrawal, A. MD; Castell, D. MDAmerican Journal of Gastroenterology: September 2006 - Volume 101 - Issue - p S67–S68 Abstracts: ESOPHAGUS Free Author InformationAuthors Digestive Disease Center, Medical University of South Carolina, Charleston, SC. Purpose: Standard esophageal manometric testing evaluates swallowing in the supine position using small boluses with a recovery period imposed between swallows. Prior manometric tests of more physiologic unrestricted eating have had limited practical application due to highly variable outcomes. The purpose of this study is to apply multichannel intraluminal impedance and manometry (MII-EM) to test esophageal function during unrestricted upright meal consumption, and to determine results with limited variability in a normal healthy population. Methods: Ten healthy volunteers with normal esophageal impedance and manometry by published criteria underwent MII-EM testing using a combined 5-channel catheter. After transnasal placement of the catheter, each subject sat upright and consumed a meal that consisted of two pieces of toasted bread and two ounces of Gatorade. During the meal the catheter continuously recorded impedance and manometry signals at 50Hz. There were no restrictions placed on eating time, and all subjects completed the meal without difficulty. Results: All data assessed by the MII-EM meal test were normally distributed. Traditional results for manometry (e.g. contraction amplitude, distal velocity) and impedance (e.g. complete bolus transit) assessed by the meal test were highly variable. Meal test impedance results with limited variability included the meal duration, number of swallows, and the percent bolus presence time (%BPT) at 10 and 5 cm above the lower esophageal sphincter (Table 1). Manometric results with limited variability included the number of peristaltic sequences, mean time between sequences, and the distal esophageal amplitudes (Table 2). Table 1 Table 2 Conclusions: MII-EM can be used to collect data with minimal variability in healthy subjects during unrestricted upright meal consumption. These methods may be used to identify abnormal motility patterns during physiologic swallowing.© The American College of Gastroenterology 2006. All Rights Reserved. Article Outline Source A Novel Test of Esophageal Function during Meal Consumption: 76 American Journal of Gastroenterology101:S67-S68, September 2006. Full-Size Email + Favorites Export View in Gallery Email to Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at American Journal of Gastroenterology. Send a copy to your email Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time. Email to Colleague Colleague's E-mail is Invalid Your Name: (optional) Your Email: Colleague's Email: Separate multiple e-mails with a (;). Message: Thought you might appreciate this item(s) I saw at American Journal of Gastroenterology. Send a copy to your email Your message has been successfully sent to your colleague. Some error has occurred while processing your request. Please try after some time. Add Item(s) to: An Existing Folder A New Folder Folder Name: Description: The item(s) has been successfully added to "". Thanks for registering! Be sure to verify your new user account in the next 24 hours, by checking your email and clicking the "verify" link. This article has been saved into your User Account, in the Favorites area, under the new folder "".