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Comparative Study Between Life Style Modifications and Sucralfate on Pregnant Women's Heartburn


Mokhtarifar, Ali, M.D.; Saalari, Parvin, R.N., M.P.H.; Akbari, Mahnaz, M.P.H.; Farivar, Mohammad, M.D.

American Journal of Gastroenterology: September 2005 - Volume 100 - Issue - p S31
Supplement Abstracts Submitted for the 70th Annual Scientific Meeting of the American College of Gastroenterology: ESOPHAGUS

Gastroentrology, Mashhad University Medical School, Mashhad, Islamic Republic of Iran; Midwifer and Nursing, School of Nursing and Midwifery, Mashhad, Islamic Republic of Iran; Public Health, School of Nursing and Midwifery, Mashhad, Islamic Republic of Iran and Gastroentrology, Boston University Medical School, Boston, M.A.

Purpose: 30 to 80 percent of pregnant women suffer from heartburn. This study was done to compare the effect of education about life style modifications and Sucralfate therapy.

Methods: This is a triple-blind clinical study involving 78 pregnant women suffering from frequent daily heartburn. By multiple stage sampling method in three groups”placebo,” Sucralfate” and “life style modifications”. At first, clinical evaluation of the average of the last three days of heart burn done. And an interview was performed to acquire information pertaining to their personal characteristics, fertility, health, and behavioral habits. After delivering medicine to its specific group and providing necessary training by educational group, after one week clinical evaluation was done again for analyzing the normal distributed variables parametrics were used and for non normal distributed variables non parametric statistics were utilized.

Results: Finding showed that there were significance difference between mean of times (Placebo P = 0.002), (sucralfate P = 0.032), (trainig P < 0.0001), intensity (placebo P = 0.003), (sucralfate P = 0.020), (training P < 0.0001), duration (placebo P < 0.000), (sucralfate P < 0.0001), (traing P <0.0001) before and after treatment. Decreasing of frequency of radiation rate after treatment were (26.1% in placebo group, 41.7% in sucralfate group and 82.6% in training group.) There were a positive linear relationship between acquired degree of education and the rate of improvement, that were for intensity (P = 0.008 R = 0.5), times (P = 0.024 R = 0.4) and duration (P = 0.011 R = 0.2).

Conclusions: Life style modification is an efficient method in treating heartburn of pregnant women, but for providing a point of view about sucralfate, it needs further research.

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